| Author | Andrade, Sonia Gumes | pt_BR |
| Author | Magalhães, Juracy Barbosa | pt_BR |
| Author | Pontes, Albélia Lima | pt_BR |
| Access date | 2016-06-27T16:25:28Z | pt_BR |
| Access date | 2016-07-07T11:39:43Z | |
| Available date | 2016-06-27T16:25:28Z | pt_BR |
| Available date | 2016-07-07T11:39:43Z | |
| Document date | 1985 | |
| Citation | ANDRADE, S. G.; MAGALHÃES, J. B.; PONTES, A. L. Evaluation of chemotherapy with benznidazole and nifurtimox in mice infected with Trypanosoma cruzi strains of different types. Bulletin ofthe World Health Organization, v. 63, n. 4, p. 721-726, 1985. | pt_BR |
| ISSN | 0042-9686 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/14622 | |
| Language | eng | pt_BR |
| Publisher | World Health Organization | pt_BR |
| Rights | open access | pt_BR |
| Subject in Portuguese | Nifurtimox | pt_BR |
| Subject in Portuguese | Benzonidazole | pt_BR |
| Subject in Portuguese | Trypanosoma cruzi | pt_BR |
| Subject in Portuguese | Xenodiagnóstico | pt_BR |
| Subject in Portuguese | Doença de Chagas | pt_BR |
| Subject in Portuguese | Animal | pt_BR |
| Title | Evaluation of chemotherapy with benznidazole and nifurtimox in mice infected with Trypanosoma cruzi strains of different types | pt_BR |
| Type | Article | pt_BR |
| Abstract | A test was made of the susceptibility of 30 strains of Trypanosoma cruzi to chemotherapy
with nifurtimox (Bay 2502) and benznidazole (Ro 7-1051). The strains had
previously been classified as type I, II, or III according to their morphobiological and
isoenzymic characteristics. Three type I strains, 14 type II strains, and 13 type III strains
were studied. Mice were infected with 2 x IO6 bloodforms ofthese parasites and treatedfor
90 days with benznidazole or nifurtimox. All the surviving mice were submitted to parasitological
tests (directparasitaemia, xenodiagnosis, inoculation in new-born mice, and haemoculture)
andserological tests (indirect immunofluorescence). As the latter remainedpositive
in about 80% of the parasitologically negative animals, the cure rates were based on the
more reliable parasitological tests. Type I strains displayed high susceptibility, type II
strains showed medium to high susceptibility, and type III strains were highly resistant to
both drugs. Thefact that aparticular strain type, with its own level ofsusceptibility, usually
predominates in a given geographical area may explain the contradictory results after
chemotherapy from different endemic areas. | pt_BR |
| Affilliation | Fundação Gonçalo Moniz, Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil | pt_BR |
| Affilliation | Fundação Gonçalo Moniz, Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil | pt_BR |
| Affilliation | Fundação Gonçalo Moniz, Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil | pt_BR |
| xmlui.metadata.dc.subject.ods | 03 Saúde e Bem-Estar | |
