Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/14622
Title: Evaluation of chemotherapy with benznidazole and nifurtimox in mice infected with Trypanosoma cruzi strains of different types
Authors: Andrade, Sonia Gumes
Magalhães, Juracy Barbosa
Pontes, Albélia Lima
Affilliation: Fundação Gonçalo Moniz, Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
Fundação Gonçalo Moniz, Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
Fundação Gonçalo Moniz, Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
Abstract: A test was made of the susceptibility of 30 strains of Trypanosoma cruzi to chemotherapy with nifurtimox (Bay 2502) and benznidazole (Ro 7-1051). The strains had previously been classified as type I, II, or III according to their morphobiological and isoenzymic characteristics. Three type I strains, 14 type II strains, and 13 type III strains were studied. Mice were infected with 2 x IO6 bloodforms ofthese parasites and treatedfor 90 days with benznidazole or nifurtimox. All the surviving mice were submitted to parasitological tests (directparasitaemia, xenodiagnosis, inoculation in new-born mice, and haemoculture) andserological tests (indirect immunofluorescence). As the latter remainedpositive in about 80% of the parasitologically negative animals, the cure rates were based on the more reliable parasitological tests. Type I strains displayed high susceptibility, type II strains showed medium to high susceptibility, and type III strains were highly resistant to both drugs. Thefact that aparticular strain type, with its own level ofsusceptibility, usually predominates in a given geographical area may explain the contradictory results after chemotherapy from different endemic areas.
keywords: Nifurtimox
Benzonidazole
Trypanosoma cruzi
Xenodiagnóstico
Doença de Chagas
Animal
Issue Date: 1985
Publisher: World Health Organization
Citation: ANDRADE, S. G.; MAGALHÃES, J. B.; PONTES, A. L. Evaluation of chemotherapy with benznidazole and nifurtimox in mice infected with Trypanosoma cruzi strains of different types. Bulletin ofthe World Health Organization, v. 63, n. 4, p. 721-726, 1985.
ISSN: 0042-9686
Copyright: open access
Appears in Collections:BA - IGM - Artigos de Periódicos

Files in This Item:
File Description SizeFormat 
Andrade SG Evaluation of....pdf816.81 kBAdobe PDFView/Open


FacebookTwitterDeliciousLinkedInGoogle BookmarksBibTex Format mendeley Endnote DiggMySpace

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.