Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/14647
Title: Enhancement of Chronic Trypanosoma cruzi Myocarditis in Dogs Treated With Low Doses of Cyclophosphamide
Authors: Andrade, Zilton de Araújo
Andrade, Sonia Gumes
Sadigursky, Moyses
Affilliation: Fundação Gonçalo Moniz, Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
Fundação Gonçalo Moniz, Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
Fundação Gonçalo Moniz, Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
Abstract: An enhancement of chronic myocarditis was obtained in dogs chronically infected with Trypanosoma cruzi protozoa soon after they were submitted to treatment with low doses of cyclophosphamide (50 mg/sq m bs three times a week for 3 weeks). Such treatment did not cause immunodepression. Myocarditis varied in intensity, but was quite severe and diffuse in some animals, with focal fibrinoid, coagulative, and lytic necrosis and invasion of disintegrating myocardial fibers by the mononuclear inflammatory cells. Untreated infected controls exhibited mild focal myocarditis, usually represented by accumulation oflymphocytes in the interstitial connective tissue. It is suggested that the administration of low doses of cyclophosphamide interfered with the immunologic suppressor network that is thought to maintain the chronic indeterminate (or latent) phase of T cruzi infection.
Keywords: Trypanosoma cruzi
Miocarditis
Cyclophosphamide
Chagas disease
Myocytes, cardiac
Animals
Dogs
Issue Date: 1987
Publisher: Elsevier
Citation: ANDRADE, Z. A.; ANDRADE, S. G.; SADIGURSKY, M. Enhancement of Chronic Trypanosoma cruzi Myocarditis in Dogs Treated With Low Doses of Cyclophosphamide. American Journal of Pathology, v. 127, n. 3, p. 467-473, 1987.
ISSN: 0002-9440
Copyright: open access
Appears in Collections:IGM - Artigos de Periódicos

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