Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/14663
Title: Strains and clones of Trypanosoma cruzi can be characterized by pattern of restriction endonuclease products of kinetoplast DNA minicircles
Authors: Morel, Carlos Medicis
Chiari, E.
Camargo, E. Plessmann
Mattei, D. M.
Romanha, A. J.
Simpson, L.
Affilliation: Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil.
Universidade Federal de Minas Gerais. ICB. Belo Horizonte, MG, Brasil.
Escola Paulista de Medicina. São Paulo, SP, Brasil.
Escola Paulista de Medicina. São Paulo, SP, Brasil.
Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Belo Horizonte, MG, Brasil.
University of California.Biology Department and Molecular Biology Institute. Los Angeles, CA, USA.
Abstract: A simple method was developed for the characterization of different strains of Tiypanosoma cruzi. T. cruzi stocks isolated from vectors or by hemoculture from patients with Chagas disease could be grouped in subpopulations having similar patterns of restriction endonuclease products of kinetoplast DNA minicircles. We designate such subpopulations by the term "schizodemes." Furthermore, it is shown that, from a given T. cruzi strain, clones with different biological properties can be isolated and identified by their restriction patterns.
Keywords: Trypanosoma cruzi
Chagas disease
kinetoplast DNA
DeCS: Trypanosoma cruzi
Doença de Chagas
DNA de Cinetoplasto
Issue Date: 1980
Publisher: National Academy of Sciences
Citation: MOREL, C. et al. Strains and clones of Trypanosoma cruzi can be characterized by pattern of restriction endonuclease products of kinetoplast DNA minicircles. Proc. Natl. Acad. Sci. USA, v.77, n.11, p.6810-6814, Nov. 1980.
Copyright: open access
Appears in Collections:MG - IRR - Artigos de Periódicos
IOC - Artigos de Periódicos

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