| Author | Contreras, Victor T. | |
| Author | Morel, Carlos Medicis | |
| Author | Goldenberg, Samuel | |
| Access date | 2016-06-28T16:12:03Z | pt_BR |
| Access date | 2016-07-07T12:16:34Z | |
| Available date | 2016-06-28T16:12:03Z | pt_BR |
| Available date | 2016-07-07T12:16:34Z | |
| Document date | 1985 | |
| Citation | CONTRERAS, Victor T.; MOREL, Carlos M.; GOLDENBERG, Samuel. Stage specific gene expression precedes morphological changes during Trypanosoma cruzi metacyclogenesis. Molecular and Biochemical Parasitology, v.14, p.83-96, 1985. | pt_BR |
| ISSN | 1872-9428 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/14684 | |
| Language | eng | pt_BR |
| Publisher | Elsevier | pt_BR |
| Rights | open access | |
| Title | Stage specific gene expression precedes morphological changes during Trypanosoma cruzi metacyclogenesis | pt_BR |
| Type | Article | |
| Abstract | The transformation of epimastigotes to metacyclic trypomastigotes of the Trypanosoma cruzi clone Dm
28c has been studied in an in vitro system consisting of artificial triatomine urine supplemented with new
born calf serum. The comparison of morphological data with gene expression products, as judged by the
proteins synthesized during differentiation, has shown that stage specific gene activation precedes by far the
morphological changes of differentiating cells. Immunoprecipitation of differentiating cell antigens with a
trypomastigote stage specific antiserum has shown that although the morphological differentiation process
takes six days to be completed, epimastigotes start to express the M 86 000 and the 78 000 trypomastigote
antigens within the first 12 h of induction. | pt_BR |
| Affilliation | Universidad de Carabobo. Departamento de Parasitologia y Microbiologia. Valencia, Venezuela. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Bioquímica e Biologia Molecular. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Bioquímica e Biologia Molecular. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Subject | Chagas' disease | pt_BR |
| Subject | Trypanosoma cruzi cloned strain | pt_BR |
| Subject | Gene expression | pt_BR |
| Subject | Cell differentiation | pt_BR |
| DeCS | Diferenciação Celular | pt_BR |
| DeCS | Doença de Chagas | pt_BR |
| DeCS | Trypanosoma cruzi | pt_BR |
| DeCS | Expressão Gênica | pt_BR |
| e-ISSN | 0166-6851 | pt_BR |
