Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/14799
Title: Active and latent tuberculosis in Brazilian correctional facilities: a cross-sectional study
Authors: Carbone, Andrea da Silva Santos
Guimarães Paião, Dayse Sanchez
Sgarbi, Renata Viebrantz Enne
Lemos, Everton Ferreira
Cazanti, Renato Fernando
Ota, Marcos Massaki
Laranjeira Junior, Alexandre
Bampi, José Victor Bortolotto
Elias, Vanessa Perreira Fayad
Simionatto, Simone
Castro, Ana Rita Coimbra Motta
Pompílio, Maurício Antonio
Oliveira, Sandra Maria do Valle de
Ko, Albert Icksang
Andrews, Jason R
Croda, Julio
Affilliation: Federal University of Grande Dourados. University Hospital. Dourados, MS, Brasil
Federal University of Grande Dourados. University Hospital. Dourados, MS, Brasil
Federal University of Grande Dourados. University Hospital. Dourados, MS, Brasil
Federal University of Grande Dourados. Faculty of Health Sciences.
Federal University of Grande Dourados. Faculty of Health Sciences.
Federal University of Grande Dourados. Faculty of Health Sciences.
Federal University of Grande Dourados. Faculty of Health Sciences.
Federal University of Grande Dourados. Faculty of Health Sciences.
Federal University of Grande Dourados. Faculty of Health Sciences.
Federal University of Grande Dourados. Faculty of Ambiental and Biological Sciences. Dourados, MS, Brasil
Federal University of Mato Grosso do Sul. Department of Biochemical Pharmacy. Campo Grande, MS, Brasil / Fundação Oswaldo Cruz. Campo Grande, MS, Brasil
Federal University of Mato Grosso do Sul. Faculty of Medicine. Campo Grande, MS, Brasil
Federal University of Mato Grosso do Sul. University Hospital. Campo Grande, MS, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil / Yale School of Public Health. Department of Epidemiology of Microbial Disease. New Haven, CT, USA.
Stanford University School of Medicine. Division of Infectious Diseases and Geographic Medicine. Stanford, CA, USA
Federal University of Grande Dourados. Faculty of Health Sciences. Dourados, MS, Brasil / Fundação Oswaldo Cruz. Campo Grande, MS, Brasil
Abstract: Background: Tuberculosis (TB) rates among prisoners are more than 20 times that of the general population in Brazil, yet there are limited data available to facilitate the development of effective interventions in this high-transmission setting. We aimed to assess risk factors for TB infection and evaluate the yield of mass screening for active disease among inmates. Methods: We administered a questionnaire and tuberculin skin test (TST) to a population-based sample of inmates from 12 prisons in Central-West Brazil and collected sera for HIV testing and two sputum samples for smear microscopy and culture from participants reporting a cough of any duration. Hierarchical Poisson regression models were used to evaluate factors associated with latent tuberculosis infection (LTBI). Results: We recruited 3,380 inmates, of which 2,861 (84.6%) were males from 8 prisons, and 519 (15.4%) were females from 4 prisons. Among the 1,020 (30%) subjects who reported a cough, we obtained sputum from 691 (68%) and identified 31 cases of active TB for a point prevalence of 917 (95% CI, 623–1302) per 100,000 prisoners. Evaluation of the two sputum smear samples failed to identify 74% of the TB cases, and 29% of the cases reported less than 2 weeks of symptoms. Obtaining a second culture identified an additional 7 (24%) cases. The prevalences of LTBI were 22.5% and 11.7% for male and female prisoners, respectively and duration of incarceration (in years) was associated with LTBI in male and female in the multivariable model (1.04, 95% CI, 1.01-1.07 and 1.34, 95% CI, 1.06-1.70, respectively). The prevalence of LTBI is 8.6% among newly incarcerated inmates, among whom LTBI prevalence significantly increased by 5% with each year of incarceration. Conclusions: Although the overall LTBI prevalence among inmates in Central-West Brazil is low, tuberculosis incidence is high (>1,800/100,00), likely due to the high force of infection among a largely susceptible inmate population. Efforts to reduce transmission in prisons may require mass screening for active TB, utilizing sputum culture in case-detection protocols.
Keywords: Tuberculosis
Prisoners
TST
Infection
Active case detection
Screening cross-sectional study
Brazil
Epidemiology
Issue Date: 2015
Publisher: BioMed Central
Citation: CARBONE, A. S. S. et al. Active and latent tuberculosis in Brazilian correctional facilities: a cross-sectional study. BMC Infectious Diseases, v. 15, p. 24-31, 2015.
DOI: 10.1186/s12879-015-0764-8
ISSN: 1471-2334
Copyright: open access
Appears in Collections:BA - IGM - Artigos de Periódicos

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