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PRETREATMENT HIV DRUG RESISTANCE AND HIV-1 SUBTYPE C ARE INDEPENDENTLY ASSOCIATED WITH VIROLOGIC FAILURE: RESULTS FROM THE MULTINATIONAL PEARLS (ACTG A5175) CLINICAL TRIAL
Kantor, Rami et al. | Date Issued: 2015
Author
Kantor, Rami
Smeaton, Laura
Vardhanabhuti, Saran
Hudelson, Sarah E.
Wallis, Carol L.
Tripathy, Srikanth
Morgado, Mariza G.
Saravanan, Shanmugham
Balakrishnan, Pachamuthu
Reitsma, Marissa
Hart, Stephen
Mellors, John W.
Halvas, Elias
Grinsztejn, Beatriz
Hosseinipour, Mina C.
Kumwenda, Johnstone
La Rosa, Alberto
Lalloo, Umesh G.
Lama, Javier R.
Rassool, Mohammed
Santos, Breno R.
Supparatpinyo, Khuanchai
Hakim, James
Flanigan, Timothy
Kumarasamy, Nagalingeswaran
Campbell, Thomas B.
Eshleman, Susan H.
Affilliation
Brown University. Department of Medicine. Division of Infectious Diseases. Providence, Rhode Island, USA.
Harvard University, Boston. Harvard School of Public Health. Center for Biostatistics in AIDS Research. Boston, Massachusetts, USA.
Harvard University, Boston. Harvard School of Public Health. Center for Biostatistics in AIDS Research. Boston, Massachusetts, USA.
Johns Hopkins University School of Medicine. Department of Pathology. Baltimore, Maryland, USA.
Lancet Laboratories. Johannesburg, South Africa.
National AIDS Research Institute. Pune, India.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de AIDS e Imunologia Molecular. Rio de Janeiro, RJ, Brasil.
YRG-CARE. Chennai, India.
YRG-CARE. Chennai, India.
Brown University. Department of Medicine. Division of Infectious Diseases. Providence, Rhode Island, USA.
Frontier Science and Technology Research Foundatio. Amherst, New York, USA.
University of Pittsburgh. Department of Medicine. Division of Infectious Diseases. Pittsburgh, Pennsylvania, USA.
University of Pittsburgh. Department of Medicine. Division of Infectious Diseases. Pittsburgh, Pennsylvania, USA.
Fundação Oswaldo Cruz. Instituto de Pesquisa Clinica Evandro Chagas. Rio de Janeiro, RJ, Brasil.
University of North Carolina Project–Malawi. Lilongwe. North Carolina, USA.
University of Malawi. College of Medicine. Department of Internal Medicine. Blantyre, Malawi.
Asociacion Civil Impacta Salud y Educacion. Barranco, Lima, Peru.
Enhancing Care Foundation. Durban, South Africa.
Asociacion Civil Impacta Salud y Educacion. Barranco, Lima, Peru.
University of Witwatersrand. Helen Joseph Hospital. Department of Medicine. Themba Lethu Clinic. Johannesburg, South Africa.
Hospital Nossa Senhora da Conceição. Serviço de Infectologia. Porto Alegre, RS, Brasil.
Chiang Mai University. Faculty of Medicine. Research Institute for Health Sciences. Thailand.
University of Zimbabwe. Department of Medicine. Harare, Zimbabwe.
Brown University. Department of Medicine. Division of Infectious Diseases. Providence, Rhode Island, USA.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de AIDS e Imunologia Molecular. Rio de Janeiro, RJ, Brasil.
University of Colorado Denver. Department of Medicine. Division of Infectious Diseases. Aurora, USA.
Johns Hopkins University School of Medicine. Department of Pathology. Baltimore, Maryland, USA.
Abstract
Evaluation of pretreatment HIV genotyping is needed globally to guide treatment programs. We examined the association of pretreatment (baseline) drug resistance and subtype with virologic failure in a multinational, randomized clinical trial that evaluated 3 antiretroviral treatment (ART) regimens and included resource-limited setting sites.
Keywords in Portuguese
HIV
Resistência à medicamentos
Subtipo
Ensaio Clínico
 
Keywords
HIV
Drug resistance
Subtype
Clinical trial
 
Publisher
Oxford University Press
Citation
KANTOR, Rami et al. Pretreatment HIV Drug Resistance and HIV-1 Subtype C Are Independently Associated With Virologic Failure: Results From the Multinational PEARLS (ACTG A5175) Clinical Trial. Clinical Infectious Diseases, v. 60, n. 10, p. 1541–1549, 2015.
DOI
10.1093/cid/civ102
ISSN
1058-4838