| Author | Marretto, Jesila Pinto M. | pt_BR |
| Author | Andrade, Sonia Gumes | pt_BR |
| Access date | 2016-07-08T19:15:02Z | pt_BR |
| Access date | 2016-07-22T13:10:43Z | |
| Available date | 2016-07-08T19:15:02Z | pt_BR |
| Available date | 2016-07-22T13:10:43Z | |
| Document date | 1994 | |
| Citation | MARRETTO, J. P. M.; ANDRADE, S. G. Biochemical behavior of Trypanosoma Cruzi strains isolated from mice submitted to specific chemotherapy. Revista da Sociedade Brasileira de Medicina Tropical, v. 27, n. 4, p. 209-215, 1994. | pt_BR |
| ISSN | 0037-8682 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/15067 | |
| Language | eng | pt_BR |
| Publisher | Sociedade Brasileira de Medicina Tropical | pt_BR |
| Rights | open access | pt_BR |
| Title | Biochemical behavior of Trypanosoma Cruzi strains isolated from mice submitted to specific chemotherapy | pt_BR |
| Type | Article | pt_BR |
| Abstract | To investigate the influence ofchemotherapy on the biochemical beha vior ofT rypanosoma
cruzi strains, three groups of mice were infected with one of three strains of T. cruzi of
different biological and isoenzymic patterns (Peruvian, 21SF and Colombian strains). Each
group was subdivided into subgroups: 1 - treated with nifurtimox; 2 - treated with
benznidazole and 3 - untreated infected controls. At the end of treatment, that lasted for 90
days, xenodiagnosis, sub inoculation of blood into new born mice and haemoculture were
performed as tests of cure. From the positive tests, 22 samples ofT. cruzi were isolatedfrom
allsubgroups. Electrophoretic analysis of the isoenzymes PGM, GP1, ALAT and AS AT failed
to show any difference between parasite strains isolated from treated and untreated mice,
which indicates that no detectable clonal selection or parasite genetic markers alterations
concerning the isoenzymes analysed have been determined by treatment with drugs of
recognized antiparasitic effect, suggesting stability of the phenotypic characteristics of the
three biological types ofT. cruzi strains. | pt_BR |
| Affilliation | Fundação Gonçalo Moniz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil | pt_BR |
| Affilliation | Fundação Gonçalo Moniz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil | pt_BR |
| Subject | Trypanosoma cruzi strains | pt_BR |
| Subject | Isoenzymes | pt_BR |
| Subject | Chemotherapy | pt_BR |
