Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/15067
Title: Biochemical behavior of Trypanosoma Cruzi strains isolated from mice submitted to specific chemotherapy
Authors: Marretto, Jesila Pinto M.
Andrade, Sonia Gumes
Affilliation: Fundação Gonçalo Moniz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
Fundação Gonçalo Moniz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
Abstract: To investigate the influence ofchemotherapy on the biochemical beha vior ofT rypanosoma cruzi strains, three groups of mice were infected with one of three strains of T. cruzi of different biological and isoenzymic patterns (Peruvian, 21SF and Colombian strains). Each group was subdivided into subgroups: 1 - treated with nifurtimox; 2 - treated with benznidazole and 3 - untreated infected controls. At the end of treatment, that lasted for 90 days, xenodiagnosis, sub inoculation of blood into new born mice and haemoculture were performed as tests of cure. From the positive tests, 22 samples ofT. cruzi were isolatedfrom allsubgroups. Electrophoretic analysis of the isoenzymes PGM, GP1, ALAT and AS AT failed to show any difference between parasite strains isolated from treated and untreated mice, which indicates that no detectable clonal selection or parasite genetic markers alterations concerning the isoenzymes analysed have been determined by treatment with drugs of recognized antiparasitic effect, suggesting stability of the phenotypic characteristics of the three biological types ofT. cruzi strains.
Keywords: Trypanosoma cruzi strains
Isoenzymes
Chemotherapy
Issue Date: 1994
Publisher: Sociedade Brasileira de Medicina Tropical
Citation: MARRETTO, J. P. M.; ANDRADE, S. G. Biochemical behavior of Trypanosoma Cruzi strains isolated from mice submitted to specific chemotherapy. Revista da Sociedade Brasileira de Medicina Tropical, v. 27, n. 4, p. 209-215, 1994.
ISSN: 0037-8682
Copyright: open access
Appears in Collections:BA - IGM - Artigos de Periódicos

Files in This Item:
File Description SizeFormat 
Marretto JPM Biochemical.pdf650.07 kBAdobe PDFView/Open



FacebookTwitterDeliciousLinkedInGoogle BookmarksBibTex Format mendeley Endnote DiggMySpace

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.