Author | Bongertz, Vera | |
Author | Jansson, M | |
Author | Flodby, P | |
Author | Morgado, Mariza Gonçalves | |
Author | Castro Filho, Bernardo Galvão | |
Author | Wigzell, H | |
Access date | 2016-08-09T13:06:48Z | |
Available date | 2016-08-09T13:06:48Z | |
Document date | 1994 | |
Citation | BONGERTZ, V. et al. Analysis of antibody specificity against the third variable region of the envelope glycoprotein gp120 of HIV-1 in plasma from HIV-1-positive individuals residing in Brazil. Brazilian Journal of Medical Biological Researach, v. 27, n. 5, p. 1225-1236, 1994. | pt_BR |
ISSN | 0100-879X | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/15204 | |
Language | eng | pt_BR |
Publisher | Associação Brasileira de Divulgação Científica | pt_BR |
Rights | open access | pt_BR |
Title | Analysis of antibody specificity against the third variable region of the envelope glycoprotein gp120 of HIV-1 in plasma from HIV-1-positive individuals residing in Brazil | pt_BR |
Type | Article | pt_BR |
Abstract | 1. Antibody specificity for the principal neutralization domain (PND) of the human immunodeficiency virus type 1 (HIV-1) was studied in plasma from 122 HIV-1-infected individuals residing in Brazil. 2. Using 8 overlapping sequential pentadecapeptides corresponding to the third variable region (V3) of 5 different HIV-1 isolates in an enzyme-linked immunosorbent assay (ELISA), a preferential recognition of the peptides with amino acid sequences corresponding to the HIV-1 isolates IIIB and MN (maximal reactivities of 60-70%) compared to the isolates SC, WMJ-2 or RF (maximal reactivities below 60%) was observed. 3. A difference was observed in the overall reactivity pattern to HIV-1 SC peptides of plasma collected from individuals residing in the Brazilian states of Rio de Janeiro and Bahia. However, a statistically significant increased recognition by Bahian plasma was only observed for the HIV-1 SC C55 peptide. 4. The mean CD4/CD8 ratio of the group of plasma with an isolate-restricted recognition of peptides (0.522 +/- 0.074) was significantly lower than that of the total group of plasma (1.00 +/- 0.18). | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Imunologia. Rio de Janeiro, RJ, Brasil | pt_BR |
Affilliation | Karolinska Institute. Department of Immunology. Stockholm, Sweden | pt_BR |
Affilliation | Karolinska Institute. Department of Immunology. Stockholm, Sweden | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Imunologia. Rio de Janeiro, RJ, Brasil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório Avançado de Saúde Pública. Salvador, BA, Brasil | pt_BR |
Affilliation | Karolinska Institute. Department of Immunology. Stockholm, Sweden | pt_BR |
Subject | HIV-1 | pt_BR |
Subject | AIDS | pt_BR |
Subject | Antibodies | pt_BR |
Subject | PND | pt_BR |
Subject | Y3 Loop | pt_BR |
Subject | Brazil | pt_BR |
Subject | Humans | pt_BR |
Subject | Molecular Sequence Data | pt_BR |
Subject | Peptide fragments | pt_BR |