Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/15249
Title: Three-year prospective study of the evolution of Manson’s Schistosomiasis in North-East Brazil
Authors: Sleigh, A. C
Mott, K. E
Hoff, R
Barreto, Maurício Lima
Mota, E. A
Maguire, J. H
Sherlock, Ítalo Rodrigues de Araújo
Weller, T. H
Affilliation: Harvard School of Public Health. Department of Tropical Public Health. Boston, USA
Harvard School of Public Health. Department of Tropical Public Health. Boston, USA
World Health Organization. Unit of Schistosomiasis and other Snail-borne Trematode Infections. Geneva, Switzerland
Universidade Federal da Bahia. Departamento Preventivo. Salvador, BA, Brasil
Harvard School of Public Health. Department of Tropical Public Health. Boston, USA
Harvard School of Public Health. Department of Tropical Public Health. Boston, USA
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
Harvard School of Public Health. Department of Tropical Public Health. Boston, USA
Abstract: A cross-sectional study of morbidity associated with Schistosoma mansoni infection in an area in North-East Brazil where the disease is endemic was carried out in 1974. The survey was repeated in 1977, before mass treatment with oxamniquine, providing a cohort of 210 individuals who had both examinations. The high prevalence of hepatomegaly (over 80%) and of splenomegaly (over 15%) contrasted with rates of 10% and 1%, respectively, in a non-endemic area. Over the 3-year period hepatomegaly spontaneously regressed in 13% of patients, and splenomegaly regressed in 56%, a phenomenon most common in older individuals with light infections. Those with heavy infections—ie, 500 or more eggs per g faeces, had an excess risk of splenomegaly of 19·6% and, of its persistence, of 61· 5%. Thus, intensity of infection was a critical factor in liver and spleen involvement, and programmes of chemotherapy that reduce infection should mitigate the risk of schistosomal morbidity.
Keywords: Schistosomiasis mansoni
Oxamniquine
Schistosomiasis
Hepatomegaly
Splenomegaly
Cross-Sectional Studies
Liver
Brazil
Humans
Prevalence
Issue Date: 1985
Publisher: Elsevier
Citation: SLEIGH, A. C. et al. Three-year prospective study of the evolution of Manson’s Schistosomiasis in North-East Brazil. The Lancet, p. 63-66, 1985.
ISSN: 0140-6736
Copyright: open access
Appears in Collections:BA - IGM - Artigos de Periódicos

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