Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/15375
Title: Macrophage activation and histopathological findings in Calomys Callosus and Swiss mice infected with several strains of Trypanosoma cruzi
Authors: Borges, Monamaris Marques
Andrade, Sonia Gumes
Pilatti, Carla Gizelle
Prado Junior, José Clovis do
Kloetzel, Judith Kardos
Affilliation: Instituto de Medicina Tropical de São Paulo. São Paulo, SP, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Salvador, BA, Brasil
Instituto de Medicina Tropical de São Paulo. São Paulo, SP, Brasil
Instituto de Medicina Tropical de São Paulo. São Paulo, SP, Brasil / Universidade de São Paulo. Departamento de Ciências Farmacêuticas. São Paulo, SP, Brasil
Instituto de Medicina Tropical de São Paulo. São Paulo, SP, Brasil / Universidade de São Paulo. Instituto de Ciências Biomédicas. Departamento de Parasitologia. São Paulo, SP, Brasil
Abstract: Peritoneal macrophage activation as measured by H2O2 release and histopathology was compared between Swiss mice and Calomys callosus, a wild rodent, reservoir of Trypanosoma cruzi, during the course of infection with four strains of this parasite. In mice F and Y strain infections result in high parasitemia and mortality while with silvatic strains Costalimai and M226 parasitemia is sub-patent, with very low mortality. H2O2 release peaked at 33,6 and 59 nM/2 x 106 cells for strains Y and F, respectively, 48 and 50 nM/2 x 106 for strains Costalimai and M226, 1t diferente days after infection. Histopathological findings of myositis, myocarditis, necrotizing artheritis and absence of macrophage parasitismo were found for strains F and Costalimai. Y strain infection presented moderate myocarditis and myositis, with parasites multiplying within macrophages.
Keywords: Macrophages
H2O2 release
Trypanosoma cruzi strains
Calomys callosus
Swiss mice
Chagas' disease
Histopathology
Issue Date: 1992
Publisher: Instituto Oswaldo Cruz
Citation: BORGES, M. M. et al. Macrophage activation and histopathological findings in Calomys Callosus and Swiss mice infected with several strains of Trypanosoma cruzi. Memórias do Instituto Oswaldo Cruz, v. 87, n. 4, p. 493-502, 1992.
ISSN: 0074-0276
Copyright: open access
Appears in Collections:BA - IGM - Artigos de Periódicos

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