| Author | Araújo, J. S. de | |
| Author | Silva, C. F. da | |
| Author | Batista, D. G. J. | |
| Author | Silva, P. B. da | |
| Author | Meuser, M. B. | |
| Author | Aiub, C. A. F. | |
| Author | Silva, M. F. V. da | |
| Author | Lima, C. F. Araújo | |
| Author | Banerjee, M. | |
| Author | Farahat, A. A. | |
| Author | Stephens, C. E. | |
| Author | Kumar, A | |
| Author | Boykin, D. W. | |
| Author | Soeiro, M. N. C. | |
| Access date | 2016-09-08T16:44:05Z | |
| Available date | 2016-09-08T16:44:05Z | |
| Document date | 2014 | |
| Citation | ARAÚJO, J. S; et al. In Vitro and In Vivo Studies of the Biological Activity of Novel Arylimidamides against Trypanosoma cruzi. Antimicrobial Agents and Chemotherapy, v.58, n.7, p.4191-4195, July 2014. | pt_BR |
| ISSN | 0066-4804 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/15725 | |
| Language | eng | pt_BR |
| Publisher | American Society for Microbiology | pt_BR |
| Rights | open access | |
| Subject in Portuguese | Trypanosoma cruzi | pt_BR |
| Subject in Portuguese | Doença de Chagas | pt_BR |
| Subject in Portuguese | Técnicas In Vitro | pt_BR |
| Title | In vitro and in vivo studies of the biological activity of novel arylimidamides against Trypanosoma cruzi | pt_BR |
| Type | Article | |
| DOI | 10.1128/AAC.01403-13 | |
| Abstract | Fifteen novel arylimidamides (AIAs) (6 bis-amidino and 9 mono-amidino analogues) were assayed against Trypanosoma cruzi in vitro and in vivo. All the bis-AIAs were more effective than the mono-AIAs, and two analogues, DB1967 and DB1989, were further evaluated in vivo. Although both of them reduced parasitemia, protection against mortality was not achieved. Our results show that the number of amidino-terminal units affects the efficacy of arylimidamides against T. cruzi. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Celular. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Celular. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Celular. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Celular. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Genética e Biologia Molecular. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Genética e Biologia Molecular. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Universidade Federal do Estado do Rio de Janeiro. Departamento de Biofísica e Biometria.Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Georgia State University. Department of Chemistry. Atlanta, Georgia, USA. | pt_BR |
| Affilliation | Georgia State University. Department of Chemistry. Atlanta, Georgia, USA / Mansoura University. Faculty of Pharmacy. Deparment of Chemistry. Mansoura, Egypt. | pt_BR |
| Affilliation | Georgia Regents University. Department of Chemistry and Physics. Augusta, GA, USA.. | pt_BR |
| Affilliation | Georgia State University. Department of Chemistry. Atlanta, Georgia, USA. | pt_BR |
| Affilliation | Georgia State University. Department of Chemistry. Atlanta, Georgia, USA. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Celular. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Subject | Trypanosoma cruzi | pt_BR |
| Subject | Chagas Disease | pt_BR |
| Subject | In vitro techiniques | pt_BR |
| Subject | Novel Arylimidamides | pt_BR |
| e-ISSN | 1098-6596 | |
| xmlui.metadata.dc.subject.ods | 03 Saúde e Bem-Estar | |
