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IN VITRO AND IN VIVO STUDIES OF THE BIOLOGICAL ACTIVITY OF NOVEL ARYLIMIDAMIDES AGAINST TRYPANOSOMA CRUZI
Araújo, J. S. de et al. | Date Issued: 2014
Author
Araújo, J. S. de
Silva, C. F. da
Batista, D. G. J.
Silva, P. B. da
Meuser, M. B.
Aiub, C. A. F.
Silva, M. F. V. da
Lima, C. F. Araújo
Banerjee, M.
Farahat, A. A.
Stephens, C. E.
Kumar, A
Boykin, D. W.
Soeiro, M. N. C.
Affilliation
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Celular. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Celular. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Celular. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Celular. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Genética e Biologia Molecular. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Genética e Biologia Molecular. Rio de Janeiro, RJ, Brasil.
Universidade Federal do Estado do Rio de Janeiro. Departamento de Biofísica e Biometria.Rio de Janeiro, RJ, Brasil.
Georgia State University. Department of Chemistry. Atlanta, Georgia, USA.
Georgia State University. Department of Chemistry. Atlanta, Georgia, USA / Mansoura University. Faculty of Pharmacy. Deparment of Chemistry. Mansoura, Egypt.
Georgia Regents University. Department of Chemistry and Physics. Augusta, GA, USA..
Georgia State University. Department of Chemistry. Atlanta, Georgia, USA.
Georgia State University. Department of Chemistry. Atlanta, Georgia, USA.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Celular. Rio de Janeiro, RJ, Brasil.
Abstract
Fifteen novel arylimidamides (AIAs) (6 bis-amidino and 9 mono-amidino analogues) were assayed against Trypanosoma cruzi in vitro and in vivo. All the bis-AIAs were more effective than the mono-AIAs, and two analogues, DB1967 and DB1989, were further evaluated in vivo. Although both of them reduced parasitemia, protection against mortality was not achieved. Our results show that the number of amidino-terminal units affects the efficacy of arylimidamides against T. cruzi.
Keywords in Portuguese
Trypanosoma cruzi
Doença de Chagas
Técnicas In Vitro
 
Keywords
Trypanosoma cruzi
Chagas Disease
In vitro techiniques
Novel Arylimidamides
 
Publisher
American Society for Microbiology
Citation
ARAÚJO, J. S; et al. In Vitro and In Vivo Studies of the Biological Activity of Novel Arylimidamides against Trypanosoma cruzi. Antimicrobial Agents and Chemotherapy, v.58, n.7, p.4191-4195, July 2014.
DOI
10.1128/AAC.01403-13
ISSN
0066-4804