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2030-01-01
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ANALYSIS OF GENETIC LINKAGE OF HIV FROM COUPLES ENROLLED IN THE HIV PREVENTION TRIALS NETWORK 052 TRIAL
Author
Eshleman, Susan H.
Hudelson, Sarah E.
Redd, Andrew D.
Wang, Lei
Debes, Rachel
Chen, Ying Q.
Martens, Craig A.
Ricklefs, Stacy M.
Selig, Ethan J.
Porcella, Stephen F.
Munshaw, Supriya
Ray, Stuart C.
Piwowar-Manning, Estelle
McCauley, Marybeth
Hosseinipour, Mina C.
Kumwenda, Johnstone
Hakim, James G.
Chariyalertsak, Suwat
de Bruyn, Guy
Grinsztejn, Beatriz
Kumarasamy, Nagalingeswaran
Makhema, Joseph
Mayer, Kenneth H.
Pilotto, Jose
Santos, Breno R.
Quinn, Thomas C.
Cohen, Myron S.
Hughes, James P.
Hudelson, Sarah E.
Redd, Andrew D.
Wang, Lei
Debes, Rachel
Chen, Ying Q.
Martens, Craig A.
Ricklefs, Stacy M.
Selig, Ethan J.
Porcella, Stephen F.
Munshaw, Supriya
Ray, Stuart C.
Piwowar-Manning, Estelle
McCauley, Marybeth
Hosseinipour, Mina C.
Kumwenda, Johnstone
Hakim, James G.
Chariyalertsak, Suwat
de Bruyn, Guy
Grinsztejn, Beatriz
Kumarasamy, Nagalingeswaran
Makhema, Joseph
Mayer, Kenneth H.
Pilotto, Jose
Santos, Breno R.
Quinn, Thomas C.
Cohen, Myron S.
Hughes, James P.
Affilliation
Johns Hopkins University School of Medicine. Department of Pathology. Baltimore, Maryland, USA.
Johns Hopkins University School of Medicine. Department of Pathology. Baltimore, Maryland, USA.
National Institutes of Health (NIH). National Institute of Allergy and Infectious Diseases (NIAID). Division of Intramural Research. Laboratory of Immunoregulation. Baltimore, Maryland, USA.
Fred Hutchinson Cancer Research Center. Vaccine and Infectious Disease Division. Seattle, Washington, USA.
University of Washington. Department of Biostatistics. Seattle, Washington, USA.
Fred Hutchinson Cancer Research Center. Vaccine and Infectious Disease Division. Seattle, Washington, USA.
NIH. MIAID. Division of Intramural Research. Rocky Mountain Laboratories. Research Technologies Section. Genomics Unit. Hamilton, Montana, USA.
NIH. MIAID. Division of Intramural Research. Rocky Mountain Laboratories. Research Technologies Section. Genomics Unit. Hamilton, Montana, USA.
NIH. MIAID. Division of Intramural Research. Rocky Mountain Laboratories. Research Technologies Section. Genomics Unit. Hamilton, Montana, USA.
NIH. MIAID. Division of Intramural Research. Rocky Mountain Laboratories. Research Technologies Section. Genomics Unit. Hamilton, Montana, USA.
Johns Hopkins University School of Medicine. Department of Medicine. Baltimore, Maryland, USA.
Johns Hopkins University School of Medicine. Department of Medicine. Baltimore, Maryland, USA.
Johns Hopkins University School of Medicine. Department of Pathology. Baltimore, Maryland, USA.
FHI 360. Health and Development Sciences Division. Arlington, Virginia, USA.
Kamuzu Central Hospital. UNC Project. Lilongwe, Malawi.
College of Medicine. Blantyre, Malawi.
University of Zimbabwe. Department of Medicine. Harare, Zimbabwe.
Chiang Mai University. Research Institute for Health Sciences. Thailand.
University of the Witwatersrand. Perinatal HIV Research Unit. Johannesburg, South Africa.
Fundação Oswaldo Cruz. Instituto de Pesquisa Clínica Evandro Chagas. Laboratorio de Pesquisa Clinica em DST/AIDS. Rio de Janeiro, RJ, Brasil.
YRG CARE Medical Ctr.. Chennai, India.
Botswana–Harvard School of Public Health AIDS Initiative Partnership. Gaborone.
Fenway Health. Boston, Massachusetts, USA.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de AIDS e Imunologia Molecular. Rio de Janeiro, RJ, Brasil / Hospital Geral de Nova Iguaçu. Nova Iguaçu, RJ, Brasil.
Hospital Nossa Senhora da Conceição. Porto Alegre, RS, Brasil.
National Institutes of Health (NIH). National Institute of Allergy and Infectious Diseases (NIAID). Division of Intramural Research. Laboratory of Immunoregulation. Baltimore, Maryland, USA / Johns Hopkins University School of Medicine. Department of Medicine. Baltimore, Maryland, USA..
University of North Carolina at Chapel Hill. Department of Medicine. NC, USA.
Fred Hutchinson Cancer Research Center. Vaccine and Infectious Disease Division. Seattle, Washington, USA. / University of Washington. Department of Biostatistics. Seattle, Washington, USA.
Johns Hopkins University School of Medicine. Department of Pathology. Baltimore, Maryland, USA.
National Institutes of Health (NIH). National Institute of Allergy and Infectious Diseases (NIAID). Division of Intramural Research. Laboratory of Immunoregulation. Baltimore, Maryland, USA.
Fred Hutchinson Cancer Research Center. Vaccine and Infectious Disease Division. Seattle, Washington, USA.
University of Washington. Department of Biostatistics. Seattle, Washington, USA.
Fred Hutchinson Cancer Research Center. Vaccine and Infectious Disease Division. Seattle, Washington, USA.
NIH. MIAID. Division of Intramural Research. Rocky Mountain Laboratories. Research Technologies Section. Genomics Unit. Hamilton, Montana, USA.
NIH. MIAID. Division of Intramural Research. Rocky Mountain Laboratories. Research Technologies Section. Genomics Unit. Hamilton, Montana, USA.
NIH. MIAID. Division of Intramural Research. Rocky Mountain Laboratories. Research Technologies Section. Genomics Unit. Hamilton, Montana, USA.
NIH. MIAID. Division of Intramural Research. Rocky Mountain Laboratories. Research Technologies Section. Genomics Unit. Hamilton, Montana, USA.
Johns Hopkins University School of Medicine. Department of Medicine. Baltimore, Maryland, USA.
Johns Hopkins University School of Medicine. Department of Medicine. Baltimore, Maryland, USA.
Johns Hopkins University School of Medicine. Department of Pathology. Baltimore, Maryland, USA.
FHI 360. Health and Development Sciences Division. Arlington, Virginia, USA.
Kamuzu Central Hospital. UNC Project. Lilongwe, Malawi.
College of Medicine. Blantyre, Malawi.
University of Zimbabwe. Department of Medicine. Harare, Zimbabwe.
Chiang Mai University. Research Institute for Health Sciences. Thailand.
University of the Witwatersrand. Perinatal HIV Research Unit. Johannesburg, South Africa.
Fundação Oswaldo Cruz. Instituto de Pesquisa Clínica Evandro Chagas. Laboratorio de Pesquisa Clinica em DST/AIDS. Rio de Janeiro, RJ, Brasil.
YRG CARE Medical Ctr.. Chennai, India.
Botswana–Harvard School of Public Health AIDS Initiative Partnership. Gaborone.
Fenway Health. Boston, Massachusetts, USA.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de AIDS e Imunologia Molecular. Rio de Janeiro, RJ, Brasil / Hospital Geral de Nova Iguaçu. Nova Iguaçu, RJ, Brasil.
Hospital Nossa Senhora da Conceição. Porto Alegre, RS, Brasil.
National Institutes of Health (NIH). National Institute of Allergy and Infectious Diseases (NIAID). Division of Intramural Research. Laboratory of Immunoregulation. Baltimore, Maryland, USA / Johns Hopkins University School of Medicine. Department of Medicine. Baltimore, Maryland, USA..
University of North Carolina at Chapel Hill. Department of Medicine. NC, USA.
Fred Hutchinson Cancer Research Center. Vaccine and Infectious Disease Division. Seattle, Washington, USA. / University of Washington. Department of Biostatistics. Seattle, Washington, USA.
Abstract
The HIV Prevention Trials Network (HPTN) 052 trial demonstrated that early initiation of antiretroviral therapy (ART) reduces human immunodeficiency virus (HIV) transmission from HIV-infected adults (index participants) to their HIV-uninfected sexual partners. We analyzed HIV from 38 index-partner pairs and 80 unrelated index participants (controls) to assess the linkage of seroconversion events.
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