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AutorSilva, Christiane França
AutorDaliry, Anissa
AutorSilva, Patrícia Bernardino da
AutorAkay, Senol
AutorBanerjee, Moloy
AutorFarahat, Abdelbasset A.
AutorFisher, Mary K.
AutorHu, Laixing
AutorKumar, Arvind
AutorLiu, Zongying
AutorStephens, Chad E.
AutorBoykin, David W.
AutorSoeiro, Maria de Nazaré Correia
Fecha de acceso2016-09-22T14:53:06Z
Fecha de disponibilización2016-09-22T14:53:06Z
Fecha de publicación2011
ReferenciaSILVA, Christiane França da; et al. The efficacy of novel arylimidamides against Trypanosoma cruzi in vitro. Parasitology, v.138, n.14, p.1863-1869, Dec. 2011.pt_BR
ISSN0031-1820pt_BR
URIhttps://www.arca.fiocruz.br/handle/icict/15912
Idiomaengpt_BR
EditorCambridge University Presspt_BR
Derechos de autorrestricted access
Palabras clave en PortuguésTrypanosoma cruzipt_BR
Palabras clave en PortuguésDoença de Chagaspt_BR
Palabras clave en PortuguésQuimioterapiapt_BR
Palabras clave en Portuguésarylimidamidespt_BR
TítuloThe efficacy of novel arylimidamides against Trypanosoma cruzi in vitropt_BR
Tipo del documentoArticle
DOI10.1017/S0031182011001429
Resumen en InglésThe present study aimed to determine the in vitro biological efficacy and selectivity of 7 novel AIAs upon bloodstream trypomastigotes and intracellular amastigotes of Trypanosoma cruzi. The biological activity of these aromatic compounds was assayed for 48 and 24 h against intracellular parasites and bloodstream forms of T. cruzi (Y strain), respectively. Additional assays were also performed to determine their potential use in blood banks by treating the bloodstream parasites with the compounds diluted in mouse blood for 24 h at 4 °C. Toxicity against mammalian cells was evaluated using primary cultures of cardiac cells incubated for 24 and 48 h with the AIAs and then cellular death rates were determined by MTT colorimetric assays. Our data demonstrated the outstanding trypanocidal effect of AIAs against T. cruzi, especially DB1853, DB1862, DB1867 and DB1868, giving IC50 values ranging between 16 and 70 nanomolar against both parasite forms. All AIAs presented superior efficacy to benznidazole and some, such as DB1868, also demonstrated promising activity as a candidate agent for blood prophylaxis. The excellent anti-trypanosomal efficacy of these novel AIAs against T. cruzi stimulates furtherin vivo studies and justifies the screening of new analogues with the goal of establishing a useful alternative therapy for Chagas disease.pt_BR
AfiliaciónFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Celular. Rio de Janeiro, RJ, Brasil.pt_BR
AfiliaciónFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Celular. Rio de Janeiro, RJ, Brasil.pt_BR
AfiliaciónFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Celular. Rio de Janeiro, RJ, Brasil.pt_BR
AfiliaciónAugusta State University. Department of Chemistry. Georgia, USA.pt_BR
AfiliaciónAugusta State University. Department of Chemistry. Georgia, USA.pt_BR
AfiliaciónAugusta State University. Department of Chemistry. Georgia, USA.pt_BR
AfiliaciónAugusta State University. Department of Chemistry and Physics. Georgia, USA.pt_BR
AfiliaciónAugusta State University. Department of Chemistry. Georgia, USA.pt_BR
AfiliaciónAugusta State University. Department of Chemistry. Georgia, USA.pt_BR
AfiliaciónAugusta State University. Department of Chemistry. Georgia, USA.pt_BR
AfiliaciónAugusta State University. Department of Chemistry and Physics. Georgia, USA.pt_BR
AfiliaciónAugusta State University. Department of Chemistry. Georgia, USA.pt_BR
AfiliaciónFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Celular. Rio de Janeiro, RJ, Brasil.pt_BR
Palavras clave en InglêsTrypanosoma cruzipt_BR
Palavras clave en InglêsChagas Diseasept_BR
Palavras clave en InglêsChemotherapypt_BR
Palavras clave en Inglêsarylimidamidespt_BR
e-ISSN1469-8161
Fecha de embargo2030-01-01
xmlui.metadata.dc.subject.ods03 Saúde e Bem-Estar


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