| Author | Oliveira, Fabiane L. de | |
| Author | Araujo-Jorge, Tania C. | |
| Author | Souza, Elen M. de | |
| Author | Oliveira, Gabriel M. de | |
| Author | Degrave, Wim M. | |
| Author | Feige, Jean-Jacques | |
| Author | Bailly, Sabine | |
| Author | Waghabi, Mariana C. | |
| Access date | 2016-09-22T17:19:04Z | |
| Available date | 2016-09-22T17:19:04Z | |
| Document date | 2012 | |
| Citation | OLIVEIRA, Fabiane L. de; et al. Oral Administration of GW788388, an Inhibitor of Transforming Growth Factor Beta Signaling, Prevents Heart Fibrosis in Chagas Disease. PLoS Negl Trop Dis., v. 6, n.6, e1696, 14p, 2012. | pt_BR |
| ISSN | 1935-2727 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/15919 | |
| Language | eng | pt_BR |
| Publisher | Public Library of Science | pt_BR |
| Rights | open access | |
| Subject in Portuguese | Doença de Chagas | pt_BR |
| Subject in Portuguese | Trypanosoma cruzi | pt_BR |
| Subject in Portuguese | Inibidores | pt_BR |
| Subject in Portuguese | GW788388 | pt_BR |
| Subject in Portuguese | Cardiomiopatia Chagásica | pt_BR |
| Title | Oral administration of GW788388, an inhibitor of transforming growth factor beta signaling, prevents heart fibrosis in Chagas disease | pt_BR |
| Type | Article | |
| DOI | 10.1371/journal.pntd.0001696 | |
| Abstract | Chagas disease induced by Trypanosoma cruzi (T. cruzi) infection is a major cause of mortality and morbidity affecting the cardiovascular system for which presently available therapies are largely inadequate. Transforming Growth Factor beta (TGFß) has been involved in several regulatory steps of T. cruzi invasion and in host tissue fibrosis. GW788388 is a new TGFß type I and type II receptor kinase inhibitor that can be orally administered. In the present work, we studied its effects in vivo during the acute phase of experimental Chagas disease. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Genômica Funcional e Bioinformática. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Celular. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Inovações em Terapias, Ensino e Bioprodutos. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Celular. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Celular. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Genômica Funcional e Bioinformática. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | INSERM, Unité 1036, Biology of Cancer and Infection. Grenoble, France / UJF-Grenoble 1. Biology of Cancer and Infection. Grenoble, France / CEA. DSV/iRTSV. Biology of Cancer and Infection. Grenoble, France. | pt_BR |
| Affilliation | INSERM, Unité 1036, Biology of Cancer and Infection. Grenoble, France / UJF-Grenoble 1. Biology of Cancer and Infection. Grenoble, France / CEA. DSV/iRTSV. Biology of Cancer and Infection. Grenoble, France. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Genômica Funcional e Bioinformática. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Subject | Chagas disease | pt_BR |
| Subject | Trypanosoma cruzi | pt_BR |
| Subject | Cardiomyopathy | pt_BR |
| Subject | GW788388 | pt_BR |
| Subject | Inhibitors | pt_BR |
| Subject | Growth Factor beta (TGFß) | pt_BR |
| e-ISSN | 1935-2735 | |
| xmlui.metadata.dc.subject.ods | 03 Saúde e Bem-Estar | |
