Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/15919
Title: Oral administration of GW788388, an inhibitor of transforming growth factor beta signaling, prevents heart fibrosis in Chagas disease
Authors: Oliveira, Fabiane L. de
Araujo-Jorge, Tania C.
Souza, Elen M. de
Oliveira, Gabriel M. de
Degrave, Wim M.
Feige, Jean-Jacques
Bailly, Sabine
Waghabi, Mariana C.
Affilliation: Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Genômica Funcional e Bioinformática. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Celular. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Inovações em Terapias, Ensino e Bioprodutos. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Celular. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Celular. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Genômica Funcional e Bioinformática. Rio de Janeiro, RJ, Brasil.
INSERM, Unité 1036, Biology of Cancer and Infection. Grenoble, France / UJF-Grenoble 1. Biology of Cancer and Infection. Grenoble, France / CEA. DSV/iRTSV. Biology of Cancer and Infection. Grenoble, France.
INSERM, Unité 1036, Biology of Cancer and Infection. Grenoble, France / UJF-Grenoble 1. Biology of Cancer and Infection. Grenoble, France / CEA. DSV/iRTSV. Biology of Cancer and Infection. Grenoble, France.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Genômica Funcional e Bioinformática. Rio de Janeiro, RJ, Brasil.
Abstract: Chagas disease induced by Trypanosoma cruzi (T. cruzi) infection is a major cause of mortality and morbidity affecting the cardiovascular system for which presently available therapies are largely inadequate. Transforming Growth Factor beta (TGFß) has been involved in several regulatory steps of T. cruzi invasion and in host tissue fibrosis. GW788388 is a new TGFß type I and type II receptor kinase inhibitor that can be orally administered. In the present work, we studied its effects in vivo during the acute phase of experimental Chagas disease.
Keywords: Chagas disease
Trypanosoma cruzi
Cardiomyopathy
GW788388
Inhibitors
Growth Factor beta (TGFß)
keywords: Doença de Chagas
Trypanosoma cruzi
Inibidores
GW788388
Cardiomiopatia Chagásica
Issue Date: 2012
Publisher: Public Library of Science
Citation: OLIVEIRA, Fabiane L. de; et al. Oral Administration of GW788388, an Inhibitor of Transforming Growth Factor Beta Signaling, Prevents Heart Fibrosis in Chagas Disease. PLoS Negl Trop Dis., v. 6, n.6, e1696, 14p, 2012.
DOI: 10.1371/journal.pntd.0001696
ISSN: 1935-2727
Copyright: open access
Appears in Collections:IOC - Artigos de Periódicos

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