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ORAL ADMINISTRATION OF GW788388, AN INHIBITOR OF TRANSFORMING GROWTH FACTOR BETA SIGNALING, PREVENTS HEART FIBROSIS IN CHAGAS DISEASE
Oliveira, Fabiane L. de et al. | Date Issued: 2012
Author
Oliveira, Fabiane L. de
Araujo-Jorge, Tania C.
Souza, Elen M. de
Oliveira, Gabriel M. de
Degrave, Wim M.
Feige, Jean-Jacques
Bailly, Sabine
Waghabi, Mariana C.
Affilliation
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Genômica Funcional e Bioinformática. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Celular. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Inovações em Terapias, Ensino e Bioprodutos. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Celular. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Celular. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Genômica Funcional e Bioinformática. Rio de Janeiro, RJ, Brasil.
INSERM, Unité 1036, Biology of Cancer and Infection. Grenoble, France / UJF-Grenoble 1. Biology of Cancer and Infection. Grenoble, France / CEA. DSV/iRTSV. Biology of Cancer and Infection. Grenoble, France.
INSERM, Unité 1036, Biology of Cancer and Infection. Grenoble, France / UJF-Grenoble 1. Biology of Cancer and Infection. Grenoble, France / CEA. DSV/iRTSV. Biology of Cancer and Infection. Grenoble, France.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Genômica Funcional e Bioinformática. Rio de Janeiro, RJ, Brasil.
Abstract
Chagas disease induced by Trypanosoma cruzi (T. cruzi) infection is a major cause of mortality and morbidity affecting the cardiovascular system for which presently available therapies are largely inadequate. Transforming Growth Factor beta (TGFß) has been involved in several regulatory steps of T. cruzi invasion and in host tissue fibrosis. GW788388 is a new TGFß type I and type II receptor kinase inhibitor that can be orally administered. In the present work, we studied its effects in vivo during the acute phase of experimental Chagas disease.
Keywords in Portuguese
Doença de Chagas
Trypanosoma cruzi
Inibidores
GW788388
Cardiomiopatia Chagásica
 
Keywords
Chagas disease
Trypanosoma cruzi
Cardiomyopathy
GW788388
Inhibitors
Growth Factor beta (TGFß)
 
Publisher
Public Library of Science
Citation
OLIVEIRA, Fabiane L. de; et al. Oral Administration of GW788388, an Inhibitor of Transforming Growth Factor Beta Signaling, Prevents Heart Fibrosis in Chagas Disease. PLoS Negl Trop Dis., v. 6, n.6, e1696, 14p, 2012.
DOI
10.1371/journal.pntd.0001696
ISSN
1935-2727