Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/15955
Title: Screening of Potential anti-Trypanosoma cruzi Candidates: In Vitro and In Vivo Studies
Authors: Soeiro, Maria de Nazaré C.
Castro, Solange Lisboa de
Affilliation: Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Celular. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Celular. Rio de Janeiro, RJ, Brasil.
Abstract: Chagas disease (CD), caused by the intracellular protozoan Trypanosoma cruzi, is a parasitic illness endemic in Latin America. In the centennial after CD discovery by Carlos Chagas (1909), although it still represents an important public health problem in these affected areas, the existing chemotherapy, based on benznidazole and nifurtimox (both introduced more than four decades ago), is far from being considered ideal due to substantial toxicity, variable effect on different parasite stocks and well-known poor activity on the chronic phase. CD is considered one of the major “neglected” diseases of the world, as commercial incentives are very limited to guarantee investments for developing and discovering novel drugs. In this context, our group has been pursuing, over the last years, the efficacy, selectivity, toxicity, cellular targets and mechanisms of action of new potential anti-T. cruzi candidates screened from an in-house compound library of different research groups in the area of medicinal chemistry. A brief review regarding these studies will be discussed, mainly related to the effect on T. cruzi of (i) diamidines and related compounds, (ii) natural naphthoquinone derivatives, and (iii) megazol derivatives.
Keywords: Trypanosoma cruzi
experimental chemotherapy
aromatic diamidines
naphthoquinones
megazol derivatives
Chagas Disease
keywords: Trypanosoma cruzi
Doença de Chagas
Quimioterapia experimental
Naftoquinonas
Diamidinas aromáticos
Derivados megazol
Issue Date: 2011
Publisher: Bentham Open
Citation: SOEIRO, Maria de Nazaré C.; CASTRO, Solange Lisboa de. Screening of Potential anti-Trypanosoma cruzi Candidates: In Vitro and In Vivo Studies. Open Medicinal Chemistry Journal, v. 5, p. 21-30, 2011.
DOI: 10.2174/1874104501105010021
ISSN: 1874-1045
Copyright: open access
Appears in Collections:IOC - Artigos de Periódicos

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