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HISTOPATOLOGIA DA INFESTAÇÃO NATURAL E EXPERIMENTAL DO TIMBU OU GAMBÁ (DIDELPHIS PARAGUAYENSIS PARAGUAIYESIS), POR SCHISTOSOMA MANSONI
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Abstract in Portuguese
Os AA. estudam as alterações histopatológicas encontradas nos vários órgãos do timbu ou gambá, marsupial muito comum no Brasil e que se mostrou bastante sensível a infestação tanto experimental como natural pelo Schistosoma mansoni. As lesões encontradas localizavam-se principalmente, no fígado, pulmão, pâncreas e intestinos. O agente patógeno era, quase sempre, o ovo, provocando uma reação granulomatosa camplicada de necrose purulenta central, nas fases iniciais, e que se caracterizava por sua relativamente rápida involução fibrocolágena. Diversos ovos com miracídio conservados foram vistos na mucosa do intestino grosso, orientados no sentido da luz intestinal.
Abstract
Histopathological studies were made of the organs of the opossum (Didelphis paraguayensis paraguayensis) infected with Schistosoma mansoni. This comon opossum is easily infected under laboratory conditions and animals with heavy natural infections were found frequently. The main lesions were found in the liver, lungs, pancreas and the intestine. However, slight involvement of other organs was also observed. Many eggs with active miracidia were found in the mucosa of the large intestine on their way to the lumen. In most instances the lesions in the organs were caused by eggs which produced a granulomatous inflamatory reaction complicated by central necrosis. Lesions in the fibro-collagenous stage found infections indicate that relatively rapid involusion of theses lesions occured. Many living worms, often paired males and females, were found in the vessels of the intestinal submucosa as well as in the serosa and in the mesenteric veins. The absence of dead worms in all of the organs examined may have been due to the short period of infection before the animals were sacrificed.
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