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| Autor | Silveira, Melise Chaves | |
| Autor | Albano, Rodolpho Mattos | |
| Autor | Asensi, Marise Dutra | |
| Autor | Assef, Ana Paula D'Alincourt Carvalho | |
| Fecha de acceso | 2016-12-08T14:32:14Z | |
| Fecha de disponibilización | 2016-12-08T14:32:14Z | |
| Fecha de publicación | 2016 | |
| Referencia | ASSEF, Ana Paula D'Alincourt Carvalho; et al. Description of genomic islands associated to the multidrug-resistant Pseudomonas aeruginosa clone ST277. Infection, Genetics and Evolution, v.42, p.60-65, 2016. | pt_BR |
| ISSN | 1567-1348 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/16484 | |
| Idioma | eng | pt_BR |
| Editor | Elsevier | pt_BR |
| Derechos de autor | restricted access | |
| Palabras clave en Portugués | Comparações genômicas | pt_BR |
| Palabras clave en Portugués | Pseudomonas aeruginosa | pt_BR |
| Palabras clave en Portugués | Clone resistente a multidrogas | pt_BR |
| Título | Description of genomic islands associated to the multidrug-resistant Pseudomonas aeruginosa clone ST277 | pt_BR |
| Tipo del documento | Article | |
| Resumen en Inglés | Multidrug-resistant Pseudomonas aeruginosa clone ST277 is disseminated in Brazil where it is mainly associated with the presence of metallo-β-lactamase SPM-1. Furthermore, it carries the class I integron In163 and a 16S rRNA methylase rmtD that confers aminoglycoside resistance. To analyze the genetic characteristics that might be responsible for the success of this endemic clone, genomes of four P. aeruginosa strains that were isolated in distinct years and in different Brazilian states were sequenced. The strains differed regarding the presence of the genes blaSPM-1 and rmtD. Genomic comparisons that included genomes of other clones that have spread worldwide from this species were also performed. These analyses revealed a 763,863 bp region in the P. aeruginosa chromosome that concentrates acquired genetic structures comprising two new genomic islands (PAGI-13 and PAGI-14), a mobile element that could be used for ST277 fingerprinting and a recently reported Integrative and Conjugative Element (ICE) associated to blaSPM-1. The genetic elements rmtD and In163 are inserted in PAGI-13 while PAGI-14 has genes encoding proteins related to type III restriction system and phages. The data reported in this study provide a basis for a clearer understanding of the genetic content of clone ST277 and illustrate the mechanisms that are responsible for the success of these endemic clones. | pt_BR |
| Afiliación | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa em Infecção Hospitalar. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Computacional e Sistemas. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Afiliación | Universidade do Estado do Rio de Janeiro. Departamento de Bioquímica. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Afiliación | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa em Infecção Hospitalar. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Afiliación | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa em Infecção Hospitalar. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Palavras clave en Inglês | Pseudomonas aeruginosa | pt_BR |
| Palavras clave en Inglês | Multidrug resistant clone | pt_BR |
| Palavras clave en Inglês | Genomic comparisons | pt_BR |
| e-ISSN | 1567-7257 | |
| Fecha de embargo | 2030-01-01 |
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