Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/16521
Title: HIV Infection Is Not Associated with Carotid Intima-Media Thickness in Brazil: A Cross-Sectional Analysis from the INI/ELSA-Brasil Study
Authors: Pacheco, Antonio G.
Grinsztejn, Beatriz
Fonseca, Maria de Jesus M. da
Griep, Rosane Härter
Lotufo, Paulo
Bensenor, Isabela
Mill, José G.
Moreira, Rodrigo de C.
Moreira, Ronaldo I.
Friedman, Ruth K.
Oliveira, Marilia Santini
Cardoso, Sandra W.
Veloso, Valdiléa G.
Chor, Dóra
Affilliation: Fundação Oswaldo Cruz. Presidência. Programa de Computação Científica. Rio de Janeiro, RJ. Brasil.
Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Escola Nacional de Saúde Pública Sergio Arouca. Departamento de Epidemiologia e Métodos Quantitativos em Saúde. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Educação em Ambiente e Saúde. Rio de Janeiro, RJ, Brasil.
Universidade de São Paulo. Escola de Medicina. São Paulo, SP, Brasil.
Universidade Federal do Espírito Santo. Departamento de Ciências Fisiológicas. Vitória, ES, Brasil.
Fundação Oswaldo Cruz. Presidência. Programa de Computação Científica. Rio de Janeiro, RJ. Brasil / Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Escola Nacional de Saúde Pública Sergio Arouca. Departamento de Epidemiologia e Métodos Quantitativos em Saúde. Rio de Janeiro, RJ, Brasil.
Abstract: Background: Carotid intima-media thickness (cIMT) has been used as an early marker of atherosclerotic disease in the general population. Recently its role among HIV-infected patients has been questioned. To date, no Brazilian study has compared cIMT in respect to HIV status. Methods We compared data from 535 patients actively followed in a prospective cohort in Rio de Janeiro (HIV group); 88 HIV-negative individuals who were nominated by patients (friend controls–FCs); and 10,943 participants of the ELSA-Brasil study. Linear regression models were used to study associations of the 3 groups and several covariables with cIMT. Propensity scores weighting (PSW) were also employed to balance data. Results: Median thickness in mm (IQR) were 0.54 (0.49,0.62); 0.58 (0.52,0.68); and 0.57 (0.49,0.70), HIV, FCs and ELSA-Brasil groups, respectively (p-value<0.001). The best linear model chosen did not include the group variables, after adjusting for all the variables chosen, showing no difference of cIMT across groups. Similar results were obtained with PSW. Several traditional CVD risk factors were also significantly associated with cIMT: female gender, higher education and higher HDL were negatively associated while risk factors were older age, current/former smoker, AMI/stroke family history, CVD history, hypertension, DM, higher BMI and total cholesterol.
Keywords: Carotid Intima-Media Thickness
INI/ELSA-Brasil Study
HIV Infection
Brazil
atherosclerotic disease
keywords: Carótida
Infeção por HIV
Espessura
Estudo ELSA-Brasil
Doença aterosclerótica
Issue Date: 2016
Publisher: Public Library of Science
Citation: PACHECO, Antonio G. et al. HIV Infection Is Not Associated with Carotid Intima-Media Thickness in Brazil: A Cross- Sectional Analysis from the INI/ELSA-Brasil Study. Plos One, v. 11, n. 7, p. 1-12, July 2016.
DOI: 10.1371/journal.pone.0158999
ISSN: 1932-6203
Copyright: open access
Appears in Collections:ENSP - Artigos de Periódicos
Presidência Fiocruz - PROCC - Artigos de Periódicos
INI - Artigos de Periódicos
IOC - Artigos de Periódicos

Files in This Item:
File Description SizeFormat 
rosane2_griep_etal_IOC_2016.pdf220.38 kBAdobe PDFView/Open



FacebookTwitterDeliciousLinkedInGoogle BookmarksBibTex Format mendeley Endnote DiggMySpace

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.