Low-grade sulfadoxine-pyrimethamine resistance in Plasmodium falciparum parasites from Lubango, Angola

Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa em Malária. Rio de Janeiro, RJ. Brasil / FIOCRUZ. Centro de Pesquisa, Diagnóstico e Treinamento em Malária (CPD-Mal) . Rio de Janeiro, RJ, Brasil / Hospital Central Dr. Antonio Agostinho Neto. Lubango, Angola / Health Progress and Investigation Network of the Portuguese-Speaking Countries Community (RIDESMal/CPLP). Lisbon, Portugal.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa em Malária. Rio de Janeiro, RJ. Brasil / FIOCRUZ. Centro de Pesquisa, Diagnóstico e Treinamento em Malária (CPD-Mal) . Rio de Janeiro, RJ, Brasil / Health Progress and Investigation Network of the Portuguese-Speaking Countries Community (RIDESMal/CPLP). Lisbon, Portugal.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa em Malária. Rio de Janeiro, RJ. Brasil / Instituto Nacional de Câncer. Laboratório de Oncovirologia. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa em Malária. Rio de Janeiro, RJ. Brasil / FIOCRUZ. Centro de Pesquisa, Diagnóstico e Treinamento em Malária (CPD-Mal) . Rio de Janeiro, RJ, Brasil / Health Progress and Investigation Network of the Portuguese-Speaking Countries Community (RIDESMal/CPLP). Lisbon, Portugal.
National Institute of Public Health. Angolan National Malaria Control Programme. Luanda, Angola / Health Progress and Investigation Network of the Portuguese-Speaking Countries Community (RIDESMal/CPLP), Lisbon, Portugal.
Institut Pasteur in Cambodia. Malaria Molecular Epidemiology Unit. Phnm Penh, Cambodia.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa em Malária. Rio de Janeiro, RJ. Brasil / FIOCRUZ. Centro de Pesquisa, Diagnóstico e Treinamento em Malária (CPD-Mal) . Rio de Janeiro, RJ, Brasil / Health Progress and Investigation Network of the Portuguese-Speaking Countries Community (RIDESMal/CPLP). Lisbon, Portugal.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa em Malária. Rio de Janeiro, RJ. Brasil / FIOCRUZ. Centro de Pesquisa, Diagnóstico e Treinamento em Malária (CPD-Mal) . Rio de Janeiro, RJ, Brasil / Health Progress and Investigation Network of the Portuguese-Speaking Countries Community (RIDESMal/CPLP). Lisbon, Portugal.

Abstract

Malaria is a major parasitic disease, affecting millions of people in endemic areas. Plasmodium falciparum parasites are responsible for the most severe cases and its resistance to anti-malarial drugs is notorious. This is a possible obstacle to the effectiveness of intermittent preventive treatment (IPT) based on sulfadoxine-pyrimethamine (SP) cures administrated to pregnant women (IPTp) during their pregnancy. As this intervention is recommended in Angola since 2006, it has assessed, in this country, the molecular profiles in P. falciparum dhfr and dhps, two polymorphic genes associated to pyrimethamine and sulfadoxine resistance, respectively.

Keywords in Portuguese

Malária
Pirimetamina
Sulfadoxina
Plasmodium falciparum
Angola

Keywords

Malaria
P.falciparum
pfdhfr
pfdhps
Sulfadoxine
Pyrimethamine
Angola

Publisher

BioMed Central

Citation

DANIEL, Elsa P. S. Kaingona; et al. Low‑grade sulfadoxine–pyrimethamine resistance in Plasmodium falciparum parasites from Lubango, Angola. Malaria Journal, v.15:309, 6p, 2016.

DOI

10.1186/s12936-016-1358-7

ISSN

1475-2875

Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/16540

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Open access

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