| Author | Medeiros, Priscila | |
| Author | Silva, Weber Laurentino da | |
| Author | Gimenez, Bruna Beatriz de Oliveira | |
| Author | Vallezi, Keren Bastos | |
| Author | Moraes, Milton Ozório | |
| Author | Souza, Vânia Niéto Brito de | |
| Author | Latini, Ana Carla Pereira | |
| Access date | 2016-12-29T15:54:27Z | |
| Available date | 2016-12-29T15:54:27Z | |
| Document date | 2016 | |
| Citation | MEDEIROS, Priscila et al. The GATA3 gene is involved in leprosy susceptibility in brazilian patients. Infection, Genetics and Evolution, v. 39, p. 194-200, Apr. 2016 | |
| ISSN | 1567-1348 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/16602 | |
| Description | Produção científica do Laboratório de Hanseníase. | pt_BR |
| Sponsorship | This study was supported by FAPESP Grant 2009/16873-8, CNPq/DECIT Grant 576051/2008-0 and Fundação Paulista Contra a Hanseníase. Priscila Medeiros received a master fellowship from CAPES-DS and Bruna Beatriz de Oliveira Gimenez received a graduation fellowship from FAPESP (Grant 2014/04143-3). | |
| Language | eng | en_US |
| Publisher | Elsevier | |
| Rights | restricted access | |
| Subject in Portuguese | Hanseníase | pt_BR |
| Subject in Portuguese | Polimorfismo | pt_BR |
| Subject in Portuguese | GATA3 | pt_BR |
| Subject in Portuguese | Estudo associado | pt_BR |
| Title | The GATA3 gene is involved in leprosy susceptibility in brazilian patients | en_US |
| Type | Article | |
| DOI | 10.1016/j.meegid.2016.01.015 | |
| Abstract | Leprosy outcome is a complex trait and the host–pathogen–environment interaction defines the emergence of the disease. Host genetic risk factors have been successfully associated to leprosy. The 10p13 chromosomal region was linked to leprosy in familial studies and GATA3 gene is a strong candidate to be part of this association. Here, we tested tag single nucleotide polymorphisms at GATA3 in two case–control samples from Brazil comprising a total of 1633 individuals using stepwise strategy. The A allele of rs10905284 marker was associated with leprosy resistance. Then, a functional analysis was conducted and showed that individuals carrying AA genotype express higher levels of GATA-3 protein in lymphocytes. So, we confirmed that the rs10905284 is a locus associated to leprosy and influences the levels of this transcription factor in the Brazilian population. | en_US |
| Affilliation | Instituto Lauro de Souza Lima. Bauru, SP, Brasil. | |
| Affilliation | Instituto Lauro de Souza Lima. Bauru, SP, Brasil. | |
| Affilliation | Instituto Lauro de Souza Lima. Bauru, SP, Brasil. | |
| Affilliation | Instituto Lauro de Souza Lima. Bauru, SP, Brasil. | |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hanseníase. Rio de Janeiro, RJ, Brasil. | |
| Affilliation | Instituto Lauro de Souza Lima. Bauru, SP, Brasil. | |
| Affilliation | Instituto Lauro de Souza Lima. Bauru, SP, Brasil. | |
| Subject | Leprosy | en_US |
| Subject | GATA3 | en_US |
| Subject | Polymorphisms | en_US |
| Subject | Association study | en_US |
| Subject | GATA-3 transcription factor | en_US |
| Subject | rs10905284 | en_US |
| Embargo date | 2030-01-01 | |
