| Author | Nunes, Bruno Tinoco | |
| Author | Telleria, Erich Loza | |
| Author | Neves, Monique da Silva | |
| Author | Marques, Christiane | |
| Author | Brito, Daisy Aline Azevedo | |
| Author | Pitaluga, André Nóbrega | |
| Author | Traub-Csekö, Yara Maria | |
| Access date | 2016-12-29T16:33:06Z | |
| Available date | 2016-12-29T16:33:06Z | |
| Document date | 2016 | |
| Citation | NUNES, Bruno Tinoco; et al. The sandfly Lutzomyia longipalpis LL5 embryonic cell line has active Toll and Imd pathways and shows immune responses to bacteria, yeast and Leishmania . Parasites & Vectors, v.8, n.222, 11p, 2016. | pt_BR |
| ISSN | 1756-3305 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/16605 | |
| Language | eng | pt_BR |
| Publisher | BioMed Central | pt_BR |
| Rights | open access | |
| Subject in Portuguese | Lutzomyia longipalpis | pt_BR |
| Subject in Portuguese | Leishmaniose | pt_BR |
| Subject in Portuguese | Linha celular embrionária LL5 | pt_BR |
| Subject in Portuguese | Resposta imune inata | pt_BR |
| Subject in Portuguese | Via de pedágio | pt_BR |
| Subject in Portuguese | Peptídeos antimicrobianos | pt_BR |
| Title | The sandfly Lutzomyia longipalpis LL5 embryonic cell line has active Toll and Imd pathways and shows immune responses to bacteria, yeast and Leishmania | pt_BR |
| Type | Article | |
| DOI | 10.1186/s13071-016-1507-4 | |
| Abstract | Lutzomyia longipalpis is the main vector of visceral leishmaniasis in Latin America. Sandfly immune responses are poorly understood. In previous work we showed that these vector insects respond to bacterial infections by modulating a defensin gene expression and activate the Imd pathway in response to Leishmania infection. Aspects of innate immune pathways in insects (including mosquito vectors of human diseases) have been revealed by studying insect cell lines, and we have previously demonstrated antiviral responses in the L. longipalpis embryonic cell line LL5. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Molecular de Parasitas e Vetores. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Molecular de Parasitas e Vetores. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Molecular de Parasitas e Vetores. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Molecular de Parasitas e Vetores. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Molecular de Parasitas e Vetores. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Molecular de Parasitas e Vetores. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Molecular de Parasitas e Vetores. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Subject | Lutzomyia longipalpis | pt_BR |
| Subject | Embryonic cell line LL5 | pt_BR |
| Subject | Innate immune response | pt_BR |
| Subject | Toll pathway | pt_BR |
| Subject | Imd pathway | pt_BR |
| Subject | Antimicrobial peptides | pt_BR |
