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THE SANDFLY LUTZOMYIA LONGIPALPIS LL5 EMBRYONIC CELL LINE HAS ACTIVE TOLL AND IMD PATHWAYS AND SHOWS IMMUNE RESPONSES TO BACTERIA, YEAST AND LEISHMANIA
Leishmaniose
Linha celular embrionária LL5
Resposta imune inata
Via de pedágio
Peptídeos antimicrobianos
Embryonic cell line LL5
Innate immune response
Toll pathway
Imd pathway
Antimicrobial peptides
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Abstract
Lutzomyia longipalpis is the main vector of visceral leishmaniasis in Latin America. Sandfly immune responses are poorly understood. In previous work we showed that these vector insects respond to bacterial infections by modulating a defensin gene expression and activate the Imd pathway in response to Leishmania infection. Aspects of innate immune pathways in insects (including mosquito vectors of human diseases) have been revealed by studying insect cell lines, and we have previously demonstrated antiviral responses in the L. longipalpis embryonic cell line LL5.
Keywords in Portuguese
Lutzomyia longipalpisLeishmaniose
Linha celular embrionária LL5
Resposta imune inata
Via de pedágio
Peptídeos antimicrobianos
Keywords
Lutzomyia longipalpisEmbryonic cell line LL5
Innate immune response
Toll pathway
Imd pathway
Antimicrobial peptides
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