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MOLECULAR CHARACTERIZATION AND PHYLOGENETIC STUDY OF COXSACKIEVIRUS A24V CAUSING OUTBREAKS OF ACUTE HEMORRHAGIC CONJUNCTIVITIS (AHC) IN BRAZIL
Tavares, Fernando Neto et al. | Date Issued: 2011
Author
Tavares, Fernando Neto
Campos, Renata de Mendonça
Burlandy, Fernanda Marcicano
Fontella, Rachel
Melo, Maria Mabel Monte de
Costa, Eliane Veiga da
Silva, Edson Elias da
Affilliation
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Enterovírus. Rio de Janeiro, RJ. Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Enterovírus. Rio de Janeiro, RJ. Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Enterovírus. Rio de Janeiro, RJ. Brasil.
Universidade Federal do Rio de Janeiro. Departamento de Genética. Laboratório de Biologia Evolutiva Teórica e Aplicada. Rio de Janeiro, RJ, Brasil.
Laboratório Central de Saúde Pública (LACEN). Laboratório de Virologia. Recife, PE, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Enterovírus. Rio de Janeiro, RJ. Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Enterovírus. Rio de Janeiro, RJ. Brasil.
Abstract
Coxsackievirus A24 variant (CA24v) is the most prevalent viral pathogen associated with acute hemorrhagic conjunctivitis (AHC) outbreaks. Sixteen years after its first outbreak in Brazil, this agent reemerged in 2003 in Brazil, spread to nearly all states and caused outbreaks until 2005. In 2009, a new outbreak occurred in the northeast region of the country. In this study, we performed a viral isolation in cell culture and characterized clinical samples collected from patients presenting symptoms during the outbreak of 2005 in Vitória, Espírito Santo State (ES) and the outbreak of 2009 in Recife, Pernambuco State (PE). We also performed a phylogenetic analysis of worldwide strains and all meaningful Brazilian isolates since 2003.
Keywords in Portuguese
Caracterização Molecular
Estudo filogenético
Conjuntivite Hemorrágica Aguda
Coxsackievirus
Brasil
 
Keywords
Coxsackievirus A24v
Acute Hemorrhagic Conjunctivitis (AHC)
Brazil
Molecular Characterization
Phylogenetic Study
 
Publisher
Public Library of Science
Citation
TAVARES, Fernando Neto; et al. Molecular Characterization and Phylogenetic Study of Coxsackievirus A24v Causing Outbreaks of Acute Hemorrhagic Conjunctivitis (AHC) in Brazil. PLoS ONE, v.6,n.8, e23206, 7p, Aug. 2011.
DOI
10.1371/journal.pone.0023206
ISSN
1932-6203