Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/16740
Title: HLA-A*01 allele: a risk factor for dengue haemorrhagic fever in Brazil’s population
Authors: Monteiro, Sérgio Pereira
Brasil, Pedro Emmanuel Alvarenga Americano do
Cabello, Giselda Maria Kalil
Souza, Rogério Valls de
Brasil, Patrícia
Georg, Ingebourg
Cabello, Pedro Hernan
Castro, Liane de
Affilliation: Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto de Pesquisa Clínica Evandro Chagas. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto de Pesquisa Clínica Evandro Chagas. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto de Pesquisa Clínica Evandro Chagas. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto de Pesquisa Clínica Evandro Chagas. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto de Pesquisa Clínica Evandro Chagas. Rio de Janeiro, RJ, Brasil.
Abstract: Severe forms of dengue, such as dengue haemorrhagic fever (DHF) and dengue shock syndrome, are examples of a complex pathogenic mechanism in which the virus, environment and host immune response interact. The influence of the host’s genetic predisposition to susceptibility or resistance to infectious diseases has been evidenced in several studies. The association of the human leukocyte antigen gene (HLA) class I alleles with DHF susceptibility or resistance has been reported in ethnically and geographically distinct populations. Due to these ethnic and viral strain differences, associations occur in each population, independently with a specific allele, which most likely explains the associations of several alleles with DHF. As the potential role of HLA alleles in the progression of DHF in Brazilian patients remains unknown, we then identified HLA-A alleles in 67 patients with dengue fever and 42 with DHF from Rio de Janeiro, Brazil, selected from 2002-2008 by the sequence-based typing technique. Statistical analysis revealed an association between the HLA-A*01 allele and DHF [odds ratio (OR) = 2.7, p = 0.01], while analysis of the HLAA* 31 allele (OR = 0.5, p = 0.11) suggested a potential protective role in DHF that should be further investigated. This study provides evidence that HLA class I alleles might be important risk factors for DHF in Brazilian patients.
Keywords: Dengue haemorrhagic fever
Dengue fever
HLA-A
HLA typing
Brazil
keywords: Dengue
Febre hemorrágica
Brasil
Febre
Issue Date: 2012
Publisher: Fundação Oswaldo Cruz. Instituto Oswaldo Cruz
Citation: MONTEIRO, Sérgio Pereira et al. HLA-A*01 allele: a risk factor for dengue haemorrhagic fever in Brazil’s population. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 107, n. 2, p. 224-230, Mar. 2012.
DOI: 10.1590/S0074-02762012000200012
ISSN: 0074-0276
Copyright: open access
Appears in Collections:INI - Artigos de Periódicos
IOC - Artigos de Periódicos

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