| Author | Paiva, Renata T. | |
| Author | Saliba, Alessandra M. | |
| Author | Fulco, Tatiana O. | |
| Author | Sales, Jorgenilce de Souza | |
| Author | Carvalho, Daniel Serra de | |
| Author | Sampaio, Elizabeth P. | |
| Author | Lopes, Ulisses G. | |
| Author | Sarno, Euzenir N. | |
| Author | Nobre, Flavio F. | |
| Access date | 2017-01-10T10:02:55Z | |
| Available date | 2017-01-10T10:02:55Z | |
| Document date | 2012 | |
| Citation | PAIVA, Renata T. et al. A framework to identify gene expression profiles in a model of inflammation induced by lipopolysaccharide after treatment with thalidomide. BMC Research Notes, v.5, n.292, 12p, 2012. | pt_BR |
| ISSN | 1756-0500 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/16764 | |
| Language | eng | pt_BR |
| Publisher | BioMed Central | pt_BR |
| Rights | open access | |
| Subject in Portuguese | Talidomida | pt_BR |
| Subject in Portuguese | Modelo de Inflamação | pt_BR |
| Subject in Portuguese | Expressão genética | pt_BR |
| Title | A framework to identify gene expression profiles in a model of inflammation induced by lipopolysaccharide after treatment with thalidomide | pt_BR |
| Type | Article | |
| DOI | 10.1186/1756-0500-5-292 | |
| Abstract | Thalidomide is an anti-inflammatory and anti-angiogenic drug currently used for the treatment of several diseases, including erythema nodosum leprosum, which occurs in patients with lepromatous leprosy. In this research, we use DNA microarray analysis to identify the impact of thalidomide on gene expression responses in human cells after lipopolysaccharide (LPS) stimulation. We employed a two-stage framework. Initially, we identified 1584 altered genes in response to LPS. Modulation of this set of genes was then analyzed in the LPS stimulated cells treated with thalidomide. | pt_BR |
| Affilliation | Universidade Federal do Rio de Janeiro. Programa de Engenharia Biomédica. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Universidade do Estado do Rio de Janeiro. Departamento de Microbiologia, Imunologia e Parasitologia. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz, Instituto Oswaldo Cruz. Laboratório de Hanseníase. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz, Instituto Oswaldo Cruz. Laboratório de Hanseníase. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz, Instituto Oswaldo Cruz. Laboratório de Hanseníase. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz, Instituto Oswaldo Cruz. Laboratório de Hanseníase. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Universidade Federal do Rio de Janeiro. Departamento de Biologia Molecular e Estrutural. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz, Instituto Oswaldo Cruz. Laboratório de Hanseníase. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Universidade Federal do Rio de Janeiro. Programa de Engenharia Biomédica. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Subject | Thalidomide | pt_BR |
| Subject | Microarray | pt_BR |
| Subject | Rank product | pt_BR |
| Subject | Inflammation model | pt_BR |
| Subject | Lipopolysaccharide | pt_BR |
| DeCS | Análise em Microsséries | pt_BR |
| DeCS | Antígenos CD14 | pt_BR |
