Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/16783
Title: Mycobacterium leprae-host-cell interactions and genetic determinants in leprosy: an overview
Authors: Pinheiro, Roberta Olmo
Salles, Jorgenilce de Souza
Sarno, Euzenir Nunes
Sampaio, Elizabeth Pereira
Affilliation: Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hanseníase. Rio de Janeiro, RJ. Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hanseníase. Rio de Janeiro, RJ. Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hanseníase. Rio de Janeiro, RJ. Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hanseníase. Rio de Janeiro, RJ. Brasil / NIH. National Institute of Health. Laboratory of Clinical Infectious Diseases, LCID. Immunopathogenesis Section. Bethesda, MD, USA.
Abstract: Leprosy, also known as Hansen's disease, is a chronic infectious disease caused by Mycobacterium leprae in which susceptibility to the mycobacteria and its clinical manifestations are attributed to the host immune response. Even though leprosy prevalence has decreased dramatically, the high number of new cases indicates active transmission. Owing to its singular features, M. leprae infection is an attractive model for investigating the regulation of human immune responses to pathogen-induced disease. Leprosy is one of the most common causes of nontraumatic peripheral neuropathy worldwide. The proportion of patients with disabilities is affected by the type of leprosy and delay in diagnosis. This article briefly reviews the clinical features as well as the immunopathological mechanisms related to the establishment of the different polar forms of leprosy, the mechanisms related to M. leprae-host cell interactions and prophylaxis and diagnosis of this complex disease. Host genetic factors are summarized and the impact of the development of interventions that prevent, reverse or limit leprosy-related nerve impairments are discussed.
Keywords: Mycobacterium leprae
Leprosy
Schwann cells
thalidomide
TNF-α
keywords: Mycobacterium leprae
Hanseníase
Células de Schwann
Talidomida
Issue Date: 2011
Publisher: Future Medicine
Citation: PINHEIRO, Roberta Olmo; et al. Mycobacterium leprae–host-cell interactions and genetic determinants in leprosy: an overview. Future Microbiol., v.6, n.2, p.217-230, Feb. 2011.
DOI: 10.2217/fmb.10.173
ISSN: 1746-0913
Copyright: restricted access
Appears in Collections:IOC - Artigos de Periódicos

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