Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/16882
Title: Antibody dynamics and spontaneous viral clearance in patients with acute hepatitis C infection in Rio de Janeiro, Brazil
Authors: Strasak, Alexander M.
Kim, Arthur Y.
Lauer, Georg M.
Sousa, Paulo S. de
Ginuino, Cleber F.
Fernandes, Carlos A.
Velloso, Carlos E.
Almeida, Adilson J. de
Oliveira, Jaqueline M. de
Yoshida, Clara F.
Schulze zur Wiesch, Julian
Paranhos-Baccalá, Gláucia
Lang, Stefan
Brant, Larry J.
Ulmer, Hanno
Strohmaier, Susanne
Kaltenbach, Lalit
Lampe, Elisabeth
Lewis-Ximenez, Lia L.
Affilliation: Innsbruck Medical University. Department of Medical Statistics, Informatics and Health Economics. Innsbruck, Austria.
Harvard Medical School. Boston, MA, USA / Massachussets General Hospital. Division of Infectious Diseases. Boston, MA, USA.
Harvard Medical School. Boston, MA, USA / Massachussets General Hospital. Gastrointestinal Unit. Boston, MA, USA.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hepatites Virais. Rio de Janeiro, RJ. Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hepatites Virais. Rio de Janeiro, RJ. Brasil.
Laboratório Central de Saúde Pública Noel Nutels. Divisão de Hepatites. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hepatites Virais. Rio de Janeiro, RJ. Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hepatites Virais. Rio de Janeiro, RJ. Brasil / Universidade Federal do Estado do Rio de Janeiro. Hospital Universitário Gaffrée Guinle. Unidade de Hepatologia. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Desenvolvimento Tecnológico em Virologia. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hepatites Virais. Rio de Janeiro, RJ. Brasil.
Universitätsklinikum Eppendorf. Medizinische Klinik I. Hamburg, Germany.
Fondation Merieux. Emerging Pathogens Laboratory. Lyon, France.
University of Innsbruck. Institute of Statistics. Innsbruck, Austria.
National Institute on Aging. Gerontology Research Center. Baltimore, USA.
Innsbruck Medical University. Department of Medical Statistics, Informatics and Health Economics. Innsbruck, Austria.
Innsbruck Medical University. Department of Medical Statistics, Informatics and Health Economics. Innsbruck, Austria.
Innsbruck Medical University. Department of Medical Statistics, Informatics and Health Economics. Innsbruck, Austria.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hepatites Virais. Rio de Janeiro, RJ. Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hepatites Virais. Rio de Janeiro, RJ. Brasil.
Abstract: Background: The anti-HCV antibody response has not been well characterized during the early phase of HCV infection and little is known about its relationship to the clinical course during this period. Methods: We analyzed serial anti-HCV antibodies longitudinally obtained from a prospective cohort of 65 patients with acute HCV infection by using a microparticle enzyme immunoassay AxSYM HCV 3.0 (Abbott Diagnostics) during the first 12 months from HCV acquisition in Rio de Janeiro, Brazil. Spontaneous viral clearance (SVC) was defined as undetectable HCV RNA in serum, in the absence of treatment, for three consecutive HCV PCR tests within 12-months of follow-up. Results: Baseline antibody values were similar among patient groups with self-limiting HCV evolution (n = 34) and persistent viremia (n = 31) [median (interquartile range) signal/cut-off ratio (s/co) 78.7 (60.7-93.8) vs. 93.9 (67.8- 111.9), p = 0.26]. During 12-months follow-up, patients with acute spontaneous resolving HCV infection showed significantly lower serial antibody response in comparison to individuals progressing to chronic infection [median (interquartile range) s/co 62.7 (35.2-85.0) vs. 98.4 (70.4-127.4), p < 0.0001]. In addition, patients with self-limiting HCV evolution exhibited an expeditious, sharp decline of serial antibody values after SVC in comparison to those measured before SVC [median (interquartile range) s/co 56.0 (25.4-79.3) vs. 79.4 (66.3-103.0), p < 0.0001]. Conclusion: Our findings indicate a rapid short-term decline of antibody values in patients with acute spontaneous resolving HCV infection.
Keywords: Acute hepatitis C virus (HCV)
Rio de Janeiro
Antibody values
keywords: Vírus agudo da hepatite C
Rio de Janeiro
Valores de anticorpos
Issue Date: 2011
Publisher: BioMed Central
Citation: STRASAK, Alexander M. et al. Antibody dynamics and spontaneous viral clearance in patients with acute hepatitis C infection in Rio de Janeiro, Brazil. BMC Infectious Diseases, v.11,n.15, 5p, 2011.
DOI: 10.1186/1471-2334-11-15
ISSN: 1471-2334
Copyright: open access
Appears in Collections:IOC - Artigos de Periódicos

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