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HEPATITIS C VIRUS (HCV) SEQUENCE VARIATION INDUCES AN HCV-SPECIFIC T-CELL PHENOTYPE ANALOGOUS TO SPONTANEOUS RESOLUTION
Kasprowicz, Victoria et al. | Date Issued: 2010
Author
Kasprowicz, Victoria
Kang, Yu-Hoi
Lucas, Michaela
Schulze zur Wiesch, Julian
Kuntzen, Thomas
Fleming, Vicki
Nolan, Brian E.
Longworth, Steven
Berical, Andrew
Bengsch, Bertram
Thimme, Robert
Lewis-Ximenez, Lia
Allen, Todd M.
Kim, Arthur Y.
Klenerman, Paul
Lauer, Georg M.
Affilliation
Harvard Medical School. Massachusetts General Hospital. Boston, MA, USA / Massachusetts Institute of Technology. Ragon Institute of Massachusetts General Hospital. Boston, MA, USA.
University of Oxford. Nuffield Department of Medicine. Peter Medawar Building for Pathogen Research. Oxford, United Kingdom.
University of Oxford. Nuffield Department of Medicine. Peter Medawar Building for Pathogen Research. Oxford, United Kingdom.
Harvard Medical School. Massachusetts General Hospital. Gastrointestinal Unit. Boston, MA, USA.
Harvard Medical School. Massachusetts General Hospital. Boston, MA, USA / Massachusetts Institute of Technology. Ragon Institute of Massachusetts General Hospital. Boston, MA, USA.
University of Oxford. Nuffield Department of Medicine. Peter Medawar Building for Pathogen Research. Oxford, United Kingdom.
Harvard Medical School. Massachusetts General Hospital. Gastrointestinal Unit. Boston, MA, USA.
Harvard Medical School. Massachusetts General Hospital. Gastrointestinal Unit. Boston, MA, USA.
Harvard Medical School. Massachusetts General Hospital. Boston, MA, USA / Massachusetts Institute of Technology. Ragon Institute of Massachusetts General Hospital. Boston, MA, USA.
Universitaet Freiburg. Medizinische Klinik. Freiburg, Germany.
Universitaet Freiburg. Medizinische Klinik. Freiburg, Germany.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Virologia. Rio de Janeiro, RJ. Brasil.
Harvard Medical School. Massachusetts General Hospital. Boston, MA, USA / Massachusetts Institute of Technology. Ragon Institute of Massachusetts General Hospital. Boston, MA, USA.
Harvard Medical School. Massachusetts General Hospital. Boston, MA, USA / Massachusetts Institute of Technology. Ragon Institute of Massachusetts General Hospital. Boston, MA, USA.
University of Oxford. Nuffield Department of Medicine. Peter Medawar Building for Pathogen Research. Oxford, United Kingdom.
Harvard Medical School. Massachusetts General Hospital. Gastrointestinal Unit. Boston, MA, USA.
Abstract
Hepatitis C virus (HCV)-specific CD8(+) T cells in persistent HCV infection are low in frequency and paradoxically show a phenotype associated with controlled infections, expressing the memory marker CD127. We addressed to what extent this phenotype is dependent on the presence of cognate antigen. We analyzed virus-specific responses in acute and chronic HCV infections and sequenced autologous virus. We show that CD127 expression is associated with decreased antigenic stimulation after either viral clearance or viral variation. Our data indicate that most CD8 T-cell responses in chronic HCV infection do not target the circulating virus and that the appearance of HCV-specific CD127(+) T cells is driven by viral variation.
Keywords in Portuguese
Virus da Hepatite V
Infecção
 
Keywords
Hepatitis C Virus (HCV)
HCV infection
 
Publisher
American Society for Microbiology
Citation
KASPROWICZ, Victoria; et al. Hepatitis C Virus (HCV) Sequence Variation Induces an HCV-Specific T-Cell Phenotype Analogous to Spontaneous Resolution . Journal of Virology, v.84, n.3, p.1656-1663, Feb. 2010.
DOI
10.1128/JVI.01499-09
ISSN
0022-538X