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Title: Lower prevalence of human immunodeficiency virus type 1 Brazilian subtype B found in northeastern Brazil with slower progression to AIDS
Authors: Araujo, Adriano Fernando da Silva
Alves, Carlos Roberto Brites
Cunha, Joana Paixão Monteiro
Santos, Luciane Amorim
Castro Filho, Bernardo Galvão
Alcantara, Luiz Carlos Júnior
Affilliation: Centro de Pesquisas Gonçalo Moniz - FIOCRUZ, Bahia, Brasil
Universidade Federal da Bahia, Brasil
Escola Bahiana de Medicina e Saúde Pública, Bahia, Brasil
Animal Models and Retroviral Vaccines Section, NCI/NIH, Bethesda, Maryland, Brasil
Abstract: Besides being extremely useful in measuring the level of HIV-1 diversity and prevalence in populations, the molecular analysis of genomic sequences provides crucial surveillance support and aids in the development of new therapies and effective vaccines. The present study focused on gag and env DNA and amino acid sequences that were generated from samples taken from 61 infected patients in the City of Salvador, Bahia, located in northeastern Brazil. In order to determine selective pressure and predict coreceptor usage, Bioinformatics tools were employed in phylogeny reconstruction. Fifty-six (91.8%) viruses were classified as belonging to subtype B, three (4.9%) from F1, and two (3.3%) from BF1 recombinants. Based on the characterization of the V3 region, the subtype B strains were represented by eight (18.2%) Brazilian variants (B'-GWGR), 20 (46.5%) European/EUA B variants (GPGR), and 15 (34.9%) GXGX variants. The mean time elapsed since diagnosis was 13 years among subtype B' and 9 years in subtype B. The mean dN/dS ratios from the GWGR, GPGR, and GXGX groups, when compared to an HXB2 reference, were 0.72, 0.77, and 0.67, respectively. Seventy-six percent of the viruses studied were predicted to use the CCR5 coreceptor for cell entry (R5 viruses), while 24% were predicted to use the CXCR4 or were classified as dual tropic viruses. The prevalence of subtypes B' and recombinant B/F1 was shown to be lower than findings from previous studies performed both in Brazil (B') and in Bahia (B/F1). The association between subtype B' and a lengthy period of time since diagnosis can be correlated with a slower disease progression in infected patients, when compared with those infected with subtype B.
DeCS: Síndrome de Imunodeficiência Adquirida/EP
Síndrome de Imunodeficiência Adquirida/VI
Dados de Sequência Molecular
Análise de Sequência de DNA
Issue Date: 2010
Citation: ARAÚJO, A. F. et al. Lower prevalence of human immunodeficiency virus type 1 Brazilian subtype B found in northeastern Brazil with slower progression to AIDS. AIDS Research and Human Retroviruses, v.26, n.11, p.1249-1254, 2010.
ISSN: 0889-2229
Copyright: open access
Appears in Collections:BA - IGM - Artigos de Periódicos

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