Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/17750
Title: The potential of secondary metabolites from plants as drugs or leads against protozoan neglected diseases - Part I.
Authors: Schmidt, Thomas Josef
Khalid, Sami Ahmed
Romanha, Alvaro Jose
Alves, Tania Maria Almeida
Biavatti, Maique Weber
Brun, Reto
Costa, Fernando Batista da
Castro, Solange Lisboa de
Ferreira, Vitor Francisco
Lacerda, Marcus Vinícius Guimarães de
Lago, Joao Henrique Ghilardi
Leon, Leonor Laura Pinto
Lopes, Norberto Peporine
Amorim, Rodrigo César das Neves
Niehues, Michael
Ogungbe, Ifedayo Victor
Pohlit, Adrian Martin
Scotti, Marcus Tullius
Setzer, William N.
Soeiro, Maria de Nazaré Correia
Steindel, Mario
Cardoso, André Gustavo Tempone
Affilliation: University of Münster. Institute of Pharmaceutical Biology and Phytochemistry. Münster, Germany
University of Science & Technology. Faculty of Pharmacy. Omdurman, Sudan
Universidade Federal de Santa Catarina. Centro de Ciências Biológicas. Departamento de Microbiologia, Immunologia e Parasitologia. Florianópolis, SC, Brasil / Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Belo Horizonte, MG, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Belo Horizonte, MG, Brasil
Universidade Federal de Santa Catarina. Departamento de Farmácia. Florianópolis, SC, Brasil
University of Basel. Swiss Tropical and Public Health Institute. Basel, Switzerland
Universidade de São Paulo. Faculdade de Ciências Farmacêuticas. Ribeirão Preto, SP, Brasil
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Celular. Rio de Janeiro, RJ, Brasil
Universidade Federal Fluminense. Departamento de Química Orgânica. Instituto de Química. Niterói, RJ, Brasil
Fundação de Medicina Tropical Heitor Vieira Dourado. Manaus, AM, Brasil
Universidade Federal de São Paulo. Instituto de Ciências Ambientais, Químicas e Farmacêuticas. Diadema, SP, Brasil
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Bioquímica de Tripanosomatideos. Rio de Janeiro, RJ, Brasil
Universidade de São Paulo. Faculdade de Ciências Farmacêuticas. Ribeirão Preto, SP, Brasil
Instituto Nacional de Pesquisa da Amazônia.Manaus, AM, Brasil
Universidade de São Paulo. Faculdade de Ciências Farmacêuticas. Ribeirão Preto, SP, Brasil
University of Alabama in Huntsville. Department of Chemistry. Huntsville, Alabama, EUA
Instituto Nacional de Pesquisa da Amazônia. Manaus, AM, Brasil
Universidade Federal da Paraíba. Centro de Ciências Aplicadas e Educação. Departamento do Engenharia e Meio Ambiente. João Pessoa, PB, Brasil
University of Alabama in Huntsville. Department of Chemistry. Huntsville, Alabama, EUA
Fundacão Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Celular. Rio de Janeiro, RJ, Brasil
Universidade Federal de Santa Catarina. Centro de Ciências Biológicas. Departamento de Microbiologia, Imunologia e Parasitologia. Florianópolis, SC, Brasil
Instituto Adolfo Lutz. Departamento de Parasitologia. São Paulo, SP, Brasil
Abstract: Infections with protozoan parasites are a major cause of disease and mortality in many tropical countries of the world. Diseases caused by species of the genera Trypanosoma (Human African Trypanosomiasis and Chagas Disease) and Leishmania (various forms of Leishmaniasis) are among the seventeen “Neglected Tropical Diseases” (NTDs) defined as such by WHO due to the neglect of financial investment into research and development of new drugs by a large part of pharmaceutical industry and neglect of public awareness in high income countries. Another major tropical protozoan disease is malaria (caused by various Plasmodium species), which -although not mentioned currently by the WHO as a neglected disease- still represents a major problem, especially to people living under poor circumstances in tropical countries. Malaria causes by far the highest number of deaths of all protozoan infections and is often (as in this review) included in the NTDs. The mentioned diseases threaten many millions of lives world-wide and they are mostly associated with poor socioeconomic and hygienic environment. Existing therapies suffer from various shortcomings, namely, a high degree of toxicity and unwanted effects, lack of availability and/or problematic application under the life conditions of affected populations. Development of new, safe and affordable drugs is therefore an urgent need. Nature has provided an innumerable number of drugs for the treatment of many serious diseases. Among the natural sources for new bioactive chemicals, plants are still predominant. Their secondary metabolism yields an immeasurable wealth of chemical structures which has been and will continue to be a source of new drugs, directly in their native form and after optimization by synthetic medicinal chemistry. The current review, published in two parts, attempts to give an overview on the potential of such plant-derived natural products as antiprotozoal leads and/or drugs in the fight against NTDs.
Keywords: Neglected tropical diseases
Trypanosoma
Leishmania
Plasmodium
natural product
monoterpene
sesquiterpene
diterpene
triterpene
keywords: Doenças tropicais neglecenciadas
Issue Date: 2012
Publisher: Ingenta Connect Bentham Science Publishing
Citation: SCHMIDT, Thomas Josef et al. The potential of secondary metabolites from plants as drugs or leads against protozoan neglected diseases - Part I. Current Medicinal Chemistry, vol.19,n. 14, p. 2128-2175, 2012.
DOI: 10.2174/092986712800229023 0929-8673
ISSN: 0929-8673
Copyright: restricted access
Appears in Collections:IOC - Artigos de Periódicos
MG - IRR - Artigos de Periódicos

Files in This Item:
File Description SizeFormat 
ve_Schmidt_Thomas_The potential Part II_CPqRR_2012.pdf1.43 MBAdobe PDF    Request a copy


FacebookTwitterDeliciousLinkedInGoogle BookmarksBibTex Format mendeley Endnote DiggMySpace

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.