Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/17846
Title: New insights into the transmissibility of leishmania infantum from dogs to sand flies: experimental vector-transmission reveals persistent parasite depots at bite sites
Authors: Aslan, Hamide
Oliveira, Fabiano
Meneses, Claudio
Castrovinci, Philip
Gomes, Regis
Teixeira, Clarissa
Derenge, Candace A.
Orandle, Marlene
Gradoni, Luigi
Oliva, Gaetano
Fischer, Laurent
Valenzuela, Jesus G.
Kamhawi, Shaden
Affilliation: Faculty of Health Science. Selahaddin Eyyubi University. Diyarbakir, Turkey/ Vector Molecular Biology Section. Laboratory of Malaria and Vector Research. National Institute of Allergy and Infectious Diseases. National Institutes of Health. Rockville, Maryland, USA.
Vector Molecular Biology Section. Laboratory of Malaria and Vector Research. National Institute of Allergy and Infectious Diseases. National Institutes of Health. Rockville, Maryland, USA.
Vector Molecular Biology Section. Laboratory of Malaria and Vector Research. National Institute of Allergy and Infectious Diseases. National Institutes of Health. Rockville, Maryland, USA.
Vector Molecular Biology Section. Laboratory of Malaria and Vector Research. National Institute of Allergy and Infectious Diseases. National Institutes of Health. Rockville, Maryland, USA.
Vector Molecular Biology Section. Laboratory of Malaria and Vector Research. National Institute of Allergy and Infectious Diseases. National Institutes of Health. Rockville, Maryland, USA / Fundação Oswaldo Cruz. Escritório Regional Fiocruz Piauí. Teresina, PI, Brasil.
Vector Molecular Biology Section. Laboratory of Malaria and Vector Research. National Institute of Allergy and Infectious Diseases. National Institutes of Health. Rockville, Maryland, USA / Fundação Oswaldo Cruz. Escritório Regional Fiocruz Piauí. Teresina, PI, Brasil.
Vector Molecular Biology Section. Laboratory of Malaria and Vector Research. National Institute of Allergy and Infectious Diseases. National Institutes of Health. Rockville, Maryland, USA.
Comparative Medicine Branch. National Institute of Allergy and Infectious Diseases. National Institutes of Health,Rockville, Maryland, USA.
Unit of Vector-Borne Diseases and International Health. Istituto Superiore di Sanità. Rome. Italy.
Department of Veterinary Medicine and Animal Productions. University Federico II. Naples, Italy.
Merial S.A.S., R&D. Laboratoire de Lyon Gerland. Paris, France.
Vector Molecular Biology Section. Laboratory of Malaria and Vector Research. National Institute of Allergy and Infectious Diseases. National Institutes of Health. Rockville, Maryland, USA.
Vector Molecular Biology Section. Laboratory of Malaria and Vector Research. National Institute of Allergy and Infectious Diseases. National Institutes of Health. Rockville, Maryland, USA.
Abstract: Canine leishmaniasis (CanL) is a chronic fatal disease of dogs and a major source of human infection through propagation of parasites in vectors. Here, we infected 8 beagles through multiple experimental vector transmissions with Leishmania infantum–infected Lutzomyia longipalpis. CanL clinical signs varied, although live parasites were recovered from all dog spleens. Splenic parasite burdens correlated positively with Leishmania-specific interleukin 10 levels, negatively with Leishmania specific interferon γ and interleukin 2 levels, and negatively with Leishmania skin test reactivity. A key finding was parasite persistence for 6 months in lesions observed at the bite sites in all dogs. These recrudesced following a second transmission performed at a distal site. Notably, sand flies efficiently acquired parasites after feeding on lesions at the primary bite site. In this study, controlled vector transmissions identify a potentially unappreciated role for skin at infectious bite sites in dogs with CanL, providing a new perspective regarding the mechanism of Leishmania transmissibility to vector sand flies.
Keywords: Canine leishmaniasis
Leishmania infantum
Lutzomyia longipalpis
Reservoir
Vector transmission
Infectivity
keywords: Leishmaniose canina
Leishmania infantum
Lutzomyia longipalpis
Reservatório
Transmissão vetorial
Infectividade
Issue Date: 2016
Publisher: Martin S. Hirsch
Citation: ASLAN, Hamide et al. New insights into the transmissibility of Leishmania infantum from dogs to sand flies: experimental transmission reveals persistent parasite depots at bite sites. The Journal of Infectious Diseases, p.1752-1761, 1 June, 2016.
ISSN: 1537-6613
Copyright: restricted access
Appears in Collections:PI - Artigos de Periódicos

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