| Author | Mendes, Graziele | |
| Author | Oliveira, Djalma de Menezes | |
| Author | Kohlhoff, Markus | |
| Author | Rosa, Carlos Augusto | |
| Author | Alves, Tânia Maria de Almeida | |
| Author | Zani, Carlos Leomar | |
| Author | Rosa, Luiz Henrique | |
| Author | Johann, Susana | |
| Author | Cota, Betania Barros | |
| Access date | 2017-02-16T18:33:41Z | |
| Available date | 2017-02-16T18:33:41Z | |
| Document date | 2016 | |
| Citation | MENDES, Graziele et al. Alkaloidal metabolites from Aspergillus felis and their activities against Paracoccidioides brasiliensis. Phytochemistry Letters, v. 17, p 28–35, 2016 | pt_BR |
| ISSN | 1874-3900 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/17848 | |
| Language | eng | pt_BR |
| Publisher | Elsevier Ltd | pt_BR |
| Rights | open access | pt_BR |
| Subject in Portuguese | Aspergillus | pt_BR |
| Title | Alkaloidal metabolites from Aspergillus felis and their activities against Paracoccidioides brasiliensis | pt_BR |
| Type | Article | pt_BR |
| Abstract | In this study, the fungus Aspergillus felis (strain UFMGCB 8030) was isolated from rocks in the Atacama Desert, Chile. Its CH2Cl2 extract exhibited antifungal activity (MIC of 1.9 μg/mL) against Paracoccidioides brasiliensis (Pb18), which is the etiological agent for paracoccidioidomycosis. The crude extract was purified, and a new cytochalasin derivative, cytochalasin Z15E (1), and one ardeemin derivative, 5-N-acetyl-8-β-isopropyl-ardeemin (4), in addition to five known secondary metabolites, rosellichalasin (2), cytochalasin E (3), gancidin (5), pseurotin A1 (6), and 2,4-dihydroxyacetophenone (7), were isolated. The structures of these compounds were confirmed by 1D and 2D NMR spectroscopy and HR-ESI⿿MS. Cytochalasin E was the most active compound with MIC an value of 3.6 μM, while the other isolated compounds exhibited weak antifungal activities (MIC values >100.0 μM). | pt_BR |
| Affilliation | Universidade Federal de Minas Gerais. Instituto de Ciencias Biologicas. Departamento de Microbiologia. Belo Horizonte, MG, Brasil | pt_BR |
| Affilliation | Universidade Estadual Sudoeste da Bahia. Departamento de Quimica. Jequié, BA, Brazil | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisa Rene Rachou. Química de Produtos Naturais Bioativos. Belo Horizonte, MG, Brasil | pt_BR |
| Affilliation | Universidade Federal de Minas Gerais. Instituto de Ciencias Biologicas. Departamento de Microbiologia. Belo Horizonte, MG, Brasil | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisa Rene Rachou. Química de Produtos Naturais Bioativos. Belo Horizonte, MG, Brasil | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisa Rene Rachou. Química de Produtos Naturais Bioativos. Belo Horizonte, MG, Brasil | pt_BR |
| Affilliation | Universidade Federal de Minas Gerais. Instituto de Ciencias Biologicas. Departamento de Microbiologia. Belo Horizonte, MG, Brasil | pt_BR |
| Affilliation | Universidade Federal de Minas Gerais. Instituto de Ciencias Biologicas. Departamento de Microbiologia. Belo Horizonte, MG, Brasil | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisa Rene Rachou. Química de Produtos Naturais Bioativos. Belo Horizonte, MG, Brasil | pt_BR |
| Subject | Aspergillus | pt_BR |
| Subject | felis | pt_BR |
| Subject | Alkaloidal | pt_BR |
| Subject | metabolites | pt_BR |
| Subject | Perhydroisoindol | pt_BR |
| Subject | Paracoccidioides | pt_BR |
| Subject | brasiliensis | pt_BR |
| Subject | Antifungal | pt_BR |
| Subject | activit | pt_BR |
| e-ISSN | http://dx.doi.org/10.1016/j.phytol.2016.06.006 | |
| Embargo date | 2021-01-01 | |
