Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/17848
Title: Alkaloidal metabolites from Aspergillus felis and their activities against Paracoccidioides brasiliensis
Authors: Mendes, Graziele
Oliveira, Djalma de Menezes
Kohlhoff, Markus
Rosa, Carlos Augusto
Alves, Tânia Maria de Almeida
Zani, Carlos Leomar
Rosa, Luiz Henrique
Johann, Susana
Cota, Betania Barros
Affilliation: Universidade Federal de Minas Gerais. Instituto de Ciencias Biologicas. Departamento de Microbiologia. Belo Horizonte, MG, Brasil
Universidade Estadual Sudoeste da Bahia. Departamento de Quimica. Jequié, BA, Brazil
Fundação Oswaldo Cruz. Centro de Pesquisa Rene Rachou. Química de Produtos Naturais Bioativos. Belo Horizonte, MG, Brasil
Universidade Federal de Minas Gerais. Instituto de Ciencias Biologicas. Departamento de Microbiologia. Belo Horizonte, MG, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisa Rene Rachou. Química de Produtos Naturais Bioativos. Belo Horizonte, MG, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisa Rene Rachou. Química de Produtos Naturais Bioativos. Belo Horizonte, MG, Brasil
Universidade Federal de Minas Gerais. Instituto de Ciencias Biologicas. Departamento de Microbiologia. Belo Horizonte, MG, Brasil
Universidade Federal de Minas Gerais. Instituto de Ciencias Biologicas. Departamento de Microbiologia. Belo Horizonte, MG, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisa Rene Rachou. Química de Produtos Naturais Bioativos. Belo Horizonte, MG, Brasil
Abstract: In this study, the fungus Aspergillus felis (strain UFMGCB 8030) was isolated from rocks in the Atacama Desert, Chile. Its CH2Cl2 extract exhibited antifungal activity (MIC of 1.9 μg/mL) against Paracoccidioides brasiliensis (Pb18), which is the etiological agent for paracoccidioidomycosis. The crude extract was purified, and a new cytochalasin derivative, cytochalasin Z15E (1), and one ardeemin derivative, 5-N-acetyl-8-β-isopropyl-ardeemin (4), in addition to five known secondary metabolites, rosellichalasin (2), cytochalasin E (3), gancidin (5), pseurotin A1 (6), and 2,4-dihydroxyacetophenone (7), were isolated. The structures of these compounds were confirmed by 1D and 2D NMR spectroscopy and HR-ESI⿿MS. Cytochalasin E was the most active compound with MIC an value of 3.6 μM, while the other isolated compounds exhibited weak antifungal activities (MIC values >100.0 μM).
Keywords: Aspergillus
felis
Alkaloidal
metabolites
Perhydroisoindol
Paracoccidioides
brasiliensis
Antifungal
activit
keywords: Aspergillus
Issue Date: 2016
Publisher: Elsevier Ltd
Citation: MENDES, Graziele et al. Alkaloidal metabolites from Aspergillus felis and their activities against Paracoccidioides brasiliensis. Phytochemistry Letters, v. 17, p 28–35, 2016
ISSN: 1874-3900
Copyright: restricted access
Appears in Collections:IRR - Artigos de Periódicos

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