Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/17852
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dc.contributor.authorSolcà, Manuela da Silva
dc.contributor.authorAndrade, Bruno de Bezerril
dc.contributor.authorAbbehusen, Melissa Moura Costa
dc.contributor.authorTeixeira, Clarissa Romero
dc.contributor.authorKhouri, Antonio Ricardo
dc.contributor.authorValenzuela, Jesus G
dc.contributor.authorKamhawi, Shaden
dc.contributor.authorBozza, Patrícia Torres
dc.contributor.authorFraga, Deborah Bittencourt Mothé
dc.contributor.authorBorges, Valeria Matos
dc.contributor.authorVeras, Patrícia Sampaio Tavares
dc.contributor.authorBrodskyn, Claudia Ida
dc.date.accessioned2017-02-17T17:54:55Z
dc.date.available2017-02-17T17:54:55Z
dc.date.issued2016
dc.identifier.citationSOLCÀ, M. S. et al. Circulating Biomarkers of Immune Activation, Oxidative Stress and Inflammation Characterize Severe Canine Visceral Leishmaniasis. Scientific Reports, v. 6, p. 32619, 2016.
dc.identifier.issn2045-2322
dc.identifier.urihttps://www.arca.fiocruz.br/handle/icict/17852
dc.language.isoeng
dc.publisherNature Publishing Group
dc.rightsopen access
dc.subject.otherBiomarcadores
dc.subject.otherLeishmaniose Visceral Canina
dc.subject.otherInflamação
dc.subject.otherAnimal
dc.subject.otherCães
dc.subject.otherSaliva
dc.subject.otherMosca
dc.titleCirculating Biomarkers of Immune Activation, Oxidative Stress and Inflammation Characterize Severe Canine Visceral Leishmaniasis
dc.typeArticle
dc.identifier.doi10.1038/srep32619
dc.description.abstractenClinical manifestations in canine visceral leishmaniasis (CVL) have not been clearly associated with immunological status or disease progression. We simultaneously assessed biomarkers of inflammation, immune activation, oxidative stress, and anti-sand fly saliva IgG concentrations in dog sera with different clinical manifestations to characterize a biosignature associated with CVL severity. In a cross-sectional exploratory study, a random population of 70 dogs from an endemic area in Brazil was classified according to CVL clinical severity and parasitological evaluation. A panel of biomarkers and anti-sand fly saliva IgG were measured in canine sera. Assessment of protein expression of profile biomarkers identified a distinct biosignature that could cluster separately animal groups with different clinical scores. Increasing severity scores were associated with a gradual decrease of LTB4 and PGE2, and a gradual increase in CXCL1 and CCL2. Discriminant analyses revealed that combined assessment of LTB4, PGE2 and CXCL1 was able to distinguish dogs with different clinical scores. Dogs with the highest clinical score values also exhibited high parasite loads and higher concentrations of anti-saliva antibodies. Our findings suggest CVL clinical severity is tightly associated with a distinct inflammatory profile hallmarked by a differential expression of circulating eicosanoids and chemokines.
dc.creator.affilliationFundação Oswaldo Cruz. Instituto de Pesquisas Gonçalo Moniz. Laboratório de Patologia e Biointervenção. Salvador, BA, Brasil
dc.creator.affilliationFundação Oswaldo Cruz. Instituto de Pesquisas Gonçalo Moniz. Laboratório Integrado de Microbiologia e Imunoregulação. Salvador, BA, Brasil / Fundação José Silveira. Multinational Organization Network Sponsoring Translational and Epidemiological Research (MONSTER) Initiative. Salvador, BA, Brasil
dc.creator.affilliationFundação Oswaldo Cruz. Instituto de Pesquisas Gonçalo Moniz. Laboratório Integrado de Microbiologia e Imunoregulação. Salvador, BA, Brasil
dc.creator.affilliationFundação Oswaldo Cruz. Fiocruz Piauí. Teresina, PI, Brasil
dc.creator.affilliationFundação Oswaldo Cruz. Instituto de Pesquisas Gonçalo Moniz. Laboratório Integrado de Microbiologia e Imunoregulação. Salvador, BA, Brasil
dc.creator.affilliationNational Institute of Allergy and Infectious Diseases. National Institutes of Health. Vector Molecular Biology Section. Laboratory of Malaria and Vector Research. Twinbrook Parkway, Rockville, USA.
dc.creator.affilliationNational Institute of Allergy and Infectious Diseases. National Institutes of Health. Vector Molecular Biology Section. Laboratory of Malaria and Vector Research. Twinbrook Parkway, Rockville, USA.
dc.creator.affilliationInstituto Oswaldo Cruz. FIOCRUZ. Bio-Manguinhos. Laboratório de Imunofarmacologia. Rio de Janeiro, Brazil
dc.creator.affilliationFundação Oswaldo Cruz. Instituto de Pesquisas Gonçalo Moniz. Laboratório de Patologia e Biointervenção. Salvador, BA, Brasil / Departamento de Medicina Veterinária Preventiva e Produção Animal, Escola de Medicina Veterinária e Zootecnia, Universidade Federal da Bahia. Salvador, BA, Brasil / Instituto Nacional de Ciência e Tecnologia para Doenças Tropicais (INCT-DT). Salvador, BA, Brasil
dc.creator.affilliationFundação Oswaldo Cruz. Instituto de Pesquisas Gonçalo Moniz. Laboratório Integrado de Microbiologia e Imunoregulação. Salvador, BA, Brasil
dc.creator.affilliationFundação Oswaldo Cruz. Instituto de Pesquisas Gonçalo Moniz. Laboratório de Patologia e Biointervenção. Salvador, BA, Brasil / Instituto Nacional de Ciência e Tecnologia para Doenças Tropicais (INCT-DT). Salvador, BA, Brasil
dc.creator.affilliationFundação Oswaldo Cruz. Instituto de Pesquisas Gonçalo Moniz. Laboratório Integrado de Microbiologia e Imunoregulação. Salvador, BA, Brasil / Instituto Nacional de Ciência e Tecnologia de Investigação em Imunologia (III-INCT). São Paulo, SP, Brasil
dc.subject.enBiomarkers
dc.subject.enCanine Visceral Leishmaniasis
dc.subject.enInflammation
dc.subject.enAnimals
dc.subject.enDogs
dc.subject.enSaliva
dc.subject.enFly
Appears in Collections:Biomanguinhos - Artigos de Periódicos
IOC - Artigos de Periódicos
PI - Artigos de Periódicos
BA - IGM - Artigos de Periódicos

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