| Author | Carvalho, Amanda Torrentes de | |
| Author | Hottz, Eugênio Damaceno | |
| Author | Marinho, Cintia Ferreira | |
| Author | Silva, Jéssica Badolato Corrêa da | |
| Author | Pinto, Luzia Maria de Oliveira | |
| Author | Fialho, Luciana Gomes | |
| Author | Bozza, Fernando A. | |
| Author | Cunha, Rivaldo Venâncio | |
| Author | Damasco, Paulo Vieira | |
| Author | Kubelka, Claire Fernandes | |
| Author | Azeredo, Elzinandes Leal de | |
| Access date | 2017-02-21T12:20:10Z | |
| Available date | 2017-02-21T12:20:10Z | |
| Document date | 2016 | |
| Citation | CARVALHO, Amanda Torrentes de et al. Characterization of clinical and immunological features in patients coinfected with dengue virus and HIV. Clinical Immunology, v. 165, p. 95-105, Mar. 2016. | pt_BR |
| ISSN | 1521-6616 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/17864 | |
| Language | eng | pt_BR |
| Publisher | Elsevier | pt_BR |
| Rights | restricted access | |
| Subject in Portuguese | Co-infecção | pt_BR |
| Subject in Portuguese | Linfócitos | pt_BR |
| Subject in Portuguese | Citocinas | pt_BR |
| Subject in Portuguese | Dengue | pt_BR |
| Subject in Portuguese | HIV | pt_BR |
| Title | Characterization of clinical and immunological features in patients coinfected with dengue virus and HIV | pt_BR |
| Type | Article | |
| DOI | 10.1016/j.clim.2016.01.005 | |
| Abstract | The pathogenesis of dengue in subjects coinfected with HIV remains largely unknown. We investigate clinical and immunological parameters in coinfected DENV/HIV patients. According to the new dengue classification, most coinfected DENV/HIV patients presented mild clinical manifestations of dengue infection. Herein, we show that DENV/HIV coinfected patients had higher CD8 T cells percentages reflected as a lower CD4/CD8 ratio. Furthermore, CCR5 expression on CD4 T cells and CD107a expression on both T subsets were significantly higher in coinfected patients when compared with monoinfected DENV and HIV individuals respectively. Increased inflammatory response was observed in treated HAART coinfected patients despite undetectable HIV load. These data indicate that DENV infection may influence the clinical profile and immune response in individuals concomitantly infected with HIV. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunologia Viral. Rio de Janeiro, RJ. Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto de Pesquisa Clínica Evandro Chagas. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunologia Viral. Rio de Janeiro, RJ. Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunologia Viral. Rio de Janeiro, RJ. Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunologia Viral. Rio de Janeiro, RJ. Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunologia Viral. Rio de Janeiro, RJ. Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto de Pesquisa Clínica Evandro Chagas. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Universidade Federal do Mato Grosso do Sul. Faculdade de Medicina. Departamento de Clínica Médica. Campo Grande, MS, Brasil. | pt_BR |
| Affilliation | Universidade Federal do Estado do Rio de Janeiro. Hospital Universitário Gaffreé Guinle. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunologia Viral. Rio de Janeiro, RJ. Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunologia Viral. Rio de Janeiro, RJ. Brasil. | pt_BR |
| Subject | HIV | pt_BR |
| Subject | Dengue | pt_BR |
| Subject | Citokines | pt_BR |
| Subject | Lymphocites | pt_BR |
| Subject | Coinfection | pt_BR |
| e-ISSN | 1521-7035 | |
| Embargo date | 2030-01-01 | |
