Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/17864
Title: Characterization of clinical and immunological features in patients coinfected with dengue virus and HIV
Authors: Carvalho, Amanda Torrentes de
Hottz, Eugênio Damaceno
Marinho, Cintia Ferreira
Silva, Jéssica Badolato Corrêa da
Pinto, Luzia Maria de Oliveira
Fialho, Luciana Gomes
Bozza, Fernando Augusto
Cunha, Rivaldo Venâncio
Damasco, Paulo Vieira
Kubelka, Claire Fernandes
Azeredo, Elzinandes Leal de
Affilliation: Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunologia Viral. Rio de Janeiro, RJ. Brasil.
Fundação Oswaldo Cruz. Instituto de Pesquisa Clínica Evandro Chagas. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunologia Viral. Rio de Janeiro, RJ. Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunologia Viral. Rio de Janeiro, RJ. Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunologia Viral. Rio de Janeiro, RJ. Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunologia Viral. Rio de Janeiro, RJ. Brasil.
Fundação Oswaldo Cruz. Instituto de Pesquisa Clínica Evandro Chagas. Rio de Janeiro, RJ, Brasil.
Universidade Federal do Mato Grosso do Sul. Faculdade de Medicina. Departamento de Clínica Médica. Campo Grande, MS, Brasil.
Universidade Federal do Estado do Rio de Janeiro. Hospital Universitário Gaffreé Guinle. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunologia Viral. Rio de Janeiro, RJ. Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunologia Viral. Rio de Janeiro, RJ. Brasil.
Abstract: The pathogenesis of dengue in subjects coinfected with HIV remains largely unknown. We investigate clinical and immunological parameters in coinfected DENV/HIV patients. According to the new dengue classification, most coinfected DENV/HIV patients presented mild clinical manifestations of dengue infection. Herein, we show that DENV/HIV coinfected patients had higher CD8 T cells percentages reflected as a lower CD4/CD8 ratio. Furthermore, CCR5 expression on CD4 T cells and CD107a expression on both T subsets were significantly higher in coinfected patients when compared with monoinfected DENV and HIV individuals respectively. Increased inflammatory response was observed in treated HAART coinfected patients despite undetectable HIV load. These data indicate that DENV infection may influence the clinical profile and immune response in individuals concomitantly infected with HIV.
Keywords: HIV
Dengue
Citokines
Lymphocites
Coinfection
keywords: Co-infecção
Linfócitos
Citocinas
Dengue
HIV
Issue Date: 2016
Publisher: Elsevier
Citation: CARVALHO, Amanda Torrentes de et al. Characterization of clinical and immunological features in patients coinfected with dengue virus and HIV. Clinical Immunology, v. 165, p. 95-105, Mar. 2016.
DOI: 10.1016/j.clim.2016.01.005
ISSN: 1521-6616
Copyright: restricted access
Appears in Collections:INI - Artigos de Periódicos
IOC - Artigos de Periódicos

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