Author | Martins, Darliane A. | |
Author | Bomfim Filho, Lucius F. | |
Author | Silva, Cleiton M. da | |
Author | Fátima, Ângelo de | |
Author | Louro, Sonia R. W. | |
Author | Batista, Denise G. J. | |
Author | Soeiro, Maria de Nazaré C. | |
Author | Carvalho, João Ernesto de | |
Author | Teixeira, Letícia R. | |
Access date | 2017-02-21T17:26:39Z | |
Available date | 2017-02-21T17:26:39Z | |
Document date | 2016 | |
Citation | MARTINS, Darliane A. et al. Copper(II) Nitroaromatic Schiff Base Complexes: Synthesis, Biological Activity and Their Interaction with DNA and Albumins. Braz. Chem. Soc., v..28, n.1, p.87-97, Jan. 2017. | pt_BR |
ISSN | 0103-5053 | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/17879 | |
Language | eng | pt_BR |
Publisher | Instituto de Química - UNICAMP | pt_BR |
Rights | open access | |
Subject in Portuguese | Albuminas | pt_BR |
Subject in Portuguese | Base de schiff | pt_BR |
Subject in Portuguese | Complexos de cobre (II) | pt_BR |
Subject in Portuguese | DNA | pt_BR |
Subject in Portuguese | Atividade biológica | pt_BR |
Title | Copper(II) Nitroaromatic Schiff Base Complexes: Synthesis, Biological Activity and Their Interaction with DNA and Albumins | pt_BR |
Type | Article | |
DOI | 10.5935/0103-5053.20160150 | |
Abstract | Copper(II) complexes of the Schiff base ligands 2-((5-nitrofuran-2-yl)methyleneamino)
phenol (HL1) and 2-(4-nitrobenzylideneamino)phenol (HL2) were prepared and characterized
using physicochemical and spectroscopic techniques. In these complexes the Schiff base ligands
acted as a bidentate donor bound to Cu2+ through the oxygen and nitrogen atoms in the deprotonated
form. The electron paramagnetic resonance spectra, carried out on [CuCl(L1)(phen)].0.5H2O
and [CuCl(L2)(phen)].2H2O complexes, showed the presence of only mononuclear forms. The
Cu2+ complexes and ligands were evaluated for their in vitro trypanocidal activity. The complex
[CuCl(L1)(phen)].0.5H2O was more active than the free Schiff base and also presented a superior
effect to benznidazole, the reference drug. The antiproliferative activity of the Schiff bases and
Cu2+ complexes were evaluated for their effect on seven tumor cell lines and showed a cytostatic
and in some cases a cytotoxic effect. These compounds also presented binding properties to
deoxyribonucleic acid (DNA) and moderate ability to quench the intrinsic fluorescence of albumins. | pt_BR |
Affilliation | Universidade Federal de Minas Gerais. Departamento de Química. Belo Horizonte, MG, Brasil. | pt_BR |
Affilliation | Universidade Federal de Minas Gerais. Departamento de Química. Belo Horizonte, MG, Brasil. | pt_BR |
Affilliation | Universidade Federal de Minas Gerais. Departamento de Química. Belo Horizonte, MG, Brasil. | pt_BR |
Affilliation | Universidade Federal de Minas Gerais. Departamento de Química. Belo Horizonte, MG, Brasil. | pt_BR |
Affilliation | Pontifícia Universidade Católica do Rio de Janeiro. Departamento de Física. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Celular. Rio de Janeiro, RJ. Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Celular. Rio de Janeiro, RJ. Brasil. | pt_BR |
Affilliation | Universidade Estadual de Campinas. Centro Pluridisciplinar de Pesquisas Químicas, Biológicas e Agrícolas. Campinas, SP, Brasil. | pt_BR |
Affilliation | Universidade Federal de Minas Gerais. Departamento de Química. Belo Horizonte, MG, Brasil. | pt_BR |
Subject | Schiff base | pt_BR |
Subject | copper(II) complexes | pt_BR |
Subject | biological activity | pt_BR |
Subject | DNA | pt_BR |
Subject | albumin | pt_BR |
e-ISSN | 1678-4790 | |