| Author | Aires, Caio Augusto Martins | |
| Author | Pereira, Polyana Silva | |
| Author | Asensi, Marise Dutra | |
| Author | Assef, Ana Paula D'Alincourt Carvalho | |
| Access date | 2017-03-09T13:30:09Z | |
| Available date | 2017-03-09T13:30:09Z | |
| Document date | 2016 | |
| Citation | AIRES, Caio Augusto Martins; et al. MgrB mutations mediating polymyxin B resistance in Klebsiella pneumoniae isolates from rectal surveillance swabs in Brazil. Antimicrobial Agents and Chemotherapy, v.61, n.3, 15p, Sept. 2016. | pt_BR |
| ISSN | 0066-4804 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/17983 | |
| Language | eng | pt_BR |
| Publisher | American Society for Microbiology | pt_BR |
| Rights | open access | |
| Subject in Portuguese | Klebsiella pneumoniae | pt_BR |
| Subject in Portuguese | Polimixina B | pt_BR |
| Subject in Portuguese | Tipagem Molecular | pt_BR |
| Subject in Portuguese | Resistência a medicamentos | pt_BR |
| Title | mgrB Mutations Mediating Polymyxin B Resistance in Klebsiella pneumoniae Isolates from Rectal Surveillance Swabs in Brazil | pt_BR |
| Type | Article | |
| DOI | 10.1128/AAC.01456-16 | |
| Abstract | We aimed to investigate polymyxin B (PMB) resistance and its molecular mechanisms in 126 Klebsiella pneumoniae isolates from rectal swabs in Brazil. Ten isolates exhibited PMB resistance with interruption of mgrB gene by insertion sequences or missense mutations. Most of the PMB-resistant isolates harbored blaKPC-2 (n = 8) and belonged to clonal complex 258 (CC258) (n = 7). These results highlight the importance of monitoring the spread of polymyxin-resistant bacteria in hospitals, since few options remain to treat multidrug-resistant isolates. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa em Infecção Hospitalar. Rio de Janeiro, RJ. Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa em Infecção Hospitalar. Rio de Janeiro, RJ. Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa em Infecção Hospitalar. Rio de Janeiro, RJ. Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa em Infecção Hospitalar. Rio de Janeiro, RJ. Brasil. | pt_BR |
| Subject | Polymyxin B resistance | pt_BR |
| Subject | Klebsiella pneumoniae | pt_BR |
| Subject | Molecular typing | pt_BR |
| Subject | MrgB mutation | pt_BR |
| e-ISSN | 1098-6596 | |
| xmlui.metadata.dc.subject.ods | 03 Saúde e Bem-Estar | |
