Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/17983
Title: mgrB Mutations Mediating Polymyxin B Resistance in Klebsiella pneumoniae Isolates from Rectal Surveillance Swabs in Brazil
Authors: Aires, Caio Augusto Martins
Pereira, Polyana Silva
Asensi, Marise Dutra
Assef, Ana Paula D'Alincourt Carvalho
Affilliation: Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa em Infecção Hospitalar. Rio de Janeiro, RJ. Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa em Infecção Hospitalar. Rio de Janeiro, RJ. Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa em Infecção Hospitalar. Rio de Janeiro, RJ. Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa em Infecção Hospitalar. Rio de Janeiro, RJ. Brasil.
Abstract: We aimed to investigate polymyxin B (PMB) resistance and its molecular mechanisms in 126 Klebsiella pneumoniae isolates from rectal swabs in Brazil. Ten isolates exhibited PMB resistance with interruption of mgrB gene by insertion sequences or missense mutations. Most of the PMB-resistant isolates harbored blaKPC-2 (n = 8) and belonged to clonal complex 258 (CC258) (n = 7). These results highlight the importance of monitoring the spread of polymyxin-resistant bacteria in hospitals, since few options remain to treat multidrug-resistant isolates.
Keywords: Polymyxin B resistance
Klebsiella pneumoniae
Molecular typing
MrgB mutation
keywords: Klebsiella pneumoniae
Polimixina B
Tipagem Molecular
Resistência a medicamentos
Issue Date: 2016
Publisher: American Society for Microbiology
Citation: AIRES, Caio Augusto Martins; et al. MgrB mutations mediating polymyxin B resistance in Klebsiella pneumoniae isolates from rectal surveillance swabs in Brazil. Antimicrobial Agents and Chemotherapy, v.61, n.3, 15p, Sept. 2016.
DOI: 10.1128/AAC.01456-16
ISSN: 0066-4804
Copyright: open access
Appears in Collections:IOC - Artigos de Periódicos

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