Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/17988
Title: Multiple introductions and onward transmission of non-pandemic HIV-1 subtype B strains in North America and Europe
Authors: Cabello, Marina
Romero, Hector
Bello, Gonzalo
Affilliation: Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de AIDS e Imunologia Molecular. Rio de Janeiro, RJ. Brasil.
Universidad de la Republica. Facultad de Ciencias-CURE. Departamento de Ecologıa y Evolucion. Laboratorio de Organizacion y Evolucion del Genoma. Montevideo, Uruguay.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de AIDS e Imunologia Molecular. Rio de Janeiro, RJ. Brasil.
Abstract: Most HIV-1 subtype B infections in North America and Europe seem to have resulted from the expansion of a single pandemic lineage (BPANDEMIC) disseminated from the United States (US). Some non-pandemic subtype B strains of Caribbean origin (BCAR) may have also reached North America and Europe, but their epidemiological relevance in those regions remains largely unknown. Here we analyze a total of 20,045 HIV-1 subtype B pol sequences from the US, Canada, and Europe, to estimate the prevalence and to reconstruct the spatiotemporal dynamics of dissemination of HIV-1 BCAR strains in those regions. We find that BCAR strains were probably disseminated from the Caribbean into North America and Europe at multiple times since the early 1970s onwards. The BCAR strains reached the US, Canada and at least 16 different European countries, where they account for a very low fraction (<5%) of subtype B infections, with exception of the Czech Republic (7.7%). We also find evidence of the onward transmission of BCAR clades in the US, Canada, the Czech Republic, Germany, Italy, Spain and the UK, as well as short-distance spreading of BCAR lineages between neighboring European countries from Central and Western Europe, and long-distance dissemination between the US and Europe.
Keywords: HIV-1 subtype B
North America
Europe
Transmission
keywords: HIV-1 subtipo B
América do Norte
Europa
Transmissão
Issue Date: 2016
Publisher: Nature Publishing Group
Citation: CABELLO, Marina; ROMERO, Hector; BELLO, Gonzalo. Multiple introductions and onward transmission of non-pandemic HIV-1 subtype B strains in North America and Europe. Scientific Reports, v.6:33971, Sept. 2016.
DOI: 10.1038/srep33971
ISSN: 2045-232
Copyright: open access
Appears in Collections:IOC - Artigos de Periódicos

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