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INTERACTION OF STROMAL AND MICROVASCULAR COMPONENTS IN KERATOCYSTIC ODONTOGENIC TUMORS
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Abstract
Little is known about the interaction of stromal components in odontogenic tumors. Thus, the aim of this study was to investigate mast cells (MCs), myofibroblasts, macrophages, and their possible association with angiogenesis and lymphangiogenesis in keratocystic odontogenic tumors (KCOTs). MATERIAL AND METHODS: Thirty cases of KCOTs
were included and analyzed by immunohistochemistry
for mast cell tryptase, a-SMA, CD34, CD163, and D240.
For comparative purpose, 15 radicular cysts (CRs) and 7
pericoronal follicles (PFs) were included.
RESULTS: There was an increase in MCs for RCs and this
difference was significant when they were compared to
KCOTS and PFs. A significant increase in the density of
MFs was observed for KCOTs when compared to RCs
and PFs (P = 0.00). No significant difference in CD163-
positive macrophages (P = 0.084) and CD34-positive vessels
(P = 0.244) densities was observed between KCOTs,
RCs, and PFs, although KCOTs showed a higher density
of all proteins. Significant difference in lymphatic vessel
density was observed for KCOTs when compared to RCs
and PFs (P = 0.00). Positive correlation was observed
between mast cell tryptase and CD34 in KCOTs
(P = 0.025).
CONCLUSIONS: A significant interaction between the
MC population and CD34-positive vessels in KCOTs
supported the hypothesis that MCs and blood vessels
contribute to the stromal scaffold of KCOT
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