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https://www.arca.fiocruz.br/handle/icict/18118
DETC-BASED BACTERIAL CELLULOSE BIO-CURATIVES FOR TOPICAL TREATMENT OF CUTANEOUS LEISHMANIASIS
Leishmania braziliensis
Drogas
Infecção
Biocurativos
Quimioterapia
Tratamento
Author
Affilliation
Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil
Universidade Estadual Paulista. Instituto de Química. Araraquara, SP, Brasil / Universidade de Araraquara-UNIARA. Araraquara, SP, Brasil
Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil
Rega Institute for Medical Research. Department of Microbiology and Immunology. K. U. Leuven, Belgium
Universidade Estadual Paulista. Instituto de Química. Araraquara, SP, Brasil
Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil
Universidade Estadual Paulista. Instituto de Química. Araraquara, SP, Brasil / Universidade de Araraquara-UNIARA. Araraquara, SP, Brasil
Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Instituto de Investigação em Imunologia (iii). INCT. São Paulo, SP, Brasil
Universidade Estadual Paulista. Instituto de Química. Araraquara, SP, Brasil / Universidade de Araraquara-UNIARA. Araraquara, SP, Brasil
Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil
Rega Institute for Medical Research. Department of Microbiology and Immunology. K. U. Leuven, Belgium
Universidade Estadual Paulista. Instituto de Química. Araraquara, SP, Brasil
Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil
Universidade Estadual Paulista. Instituto de Química. Araraquara, SP, Brasil / Universidade de Araraquara-UNIARA. Araraquara, SP, Brasil
Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Instituto de Investigação em Imunologia (iii). INCT. São Paulo, SP, Brasil
Abstract
The treatment of leishmaniasis still relies on drugs with potentially serious adverse effects. Herein, we tested a topical formulation of bacterial cellulose (BC) membranes containing Diethyldithiocarbamate (DETC), a superoxide dismutase 1 inhibitor. Leishmania-infected macrophages exposed to BC-DETC resulted in parasite killing, without pronounced toxic effects to host cells. This outcome was associated with lower SOD1 activity and higher production of superoxide and cytokine mediators. Topical application of BC-DETC significantly decreased lesion size, parasite load and the inflammatory response at the infection site, as well as the production of both IFN-γ and TNF. Combination of topical BC-DETC plus intraperitoneal Sb(v) also significantly reduced disease development and parasite load. The leishmanicidal effect of BC-DETC was extended to human macrophages infected with L. braziliensis, highlighting the feasibility of BC-DETC as a topical formulation for chemotherapy of cutaneous leishmaniasis caused by L. braziliensis.
Keywords in Portuguese
LeishmaniaLeishmania braziliensis
Drogas
Infecção
Biocurativos
Quimioterapia
Tratamento
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