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2030-01-01
Sustainable Development Goals
03 Saúde e Bem-Estar
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EXTRATHYMIC CD4+CD8+ LYMPHOCYTES IN CHAGAS DISEASE: POSSIBLE RELATIONSHIP WITH AN IMMUNOENDOCRINE IMBALANCE
Pérez, Ana R. et al. | Date Issued: 2012
Author
Pérez, Ana R.
Morrot, Alexandre
Berbert, Luiz R.
Terra-Granado, Eugenia
Savino, Wilson
Affilliation
National University of Rosario. Faculty of Medical Sciences. Institute of Immunology. Rosario, Argentina.
Universidade Federal do Rio de Janeiro. Instituto de Microbiologia. Departamento de Imunologia. Rio de Janeiro, RJ, Brasil.l
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa sobre o Timo. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa sobre o Timo. Rio de Janeiro, RJ, Brasil / Instituto Nacional de Câncer. Centro de Pesquisa. Programa de Hematologia e Oncologia.Pediátrica. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa sobre o Timo. Rio de Janeiro, RJ, Brasil.
Abstract
Double-positive (DP) CD4(+) CD8(+) T cells normally represent a thymic subpopulation that is developed in the thymus as a precursor of CD4(+) or CD8(+) single-positive T cells. Recent evidence has shown that DP cells with an activated phenotype can be tracked in secondary lymph organs. The detection of an activated DP population in the periphery, a population that expresses T cell receptors unselected during thymic negative selection in murine models of Trypanosoma cruzi infection and in humans with Chagas disease, raise new questions about the relevance of this population in the pathogenesis of this major parasitic disease and its possible link with immunoendocrine alterations.
Keywords in Portuguese
Doença de Chagas
infecção por Trypanosoma cruzi
idrocortisona
Desidroepiandrosterona
Timo
Relação CD4-CD8
 
Keywords
CD4+CD8+ double-positive CD4+CD8+ T cell
thymus
Chagas Disease
Trypanosoma cruzi infection
cortisol
dehydroepiandrosterone
 
Publisher
Wiley
Citation
PÈREZ, Ana R. et al. Extrathymic CD4+CD8+ lymphocytes in Chagas disease: possible relationship with an immunoendocrine imbalance. Ann. N.Y. Acad. Sci., v.1262, p.27–36, 2012.
DOI
10.1111/j.1749-6632.2012.06627.x
ISSN
0077-8923