Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/18641
Title: High HIV-1 Genetic Diversity in Patients from Northern Brazil
Authors: Costa, Carolina Marinho da
Oliveira, Cintia Mara Costa de
Melo, Yonne Francis Chehuan de
Delatorre, Edson
Bello, Gonzalo
Couto-Fernandez, Jose Carlos
Affilliation: Secretaria de Estado da Saúde do Amazonas. Fundação de Medicina Tropical Dr. Heitor Vieira Dourado. Laboratório de Genotipagem de HIV. Manaus, AM, Brasil / Universidade do Estado do Amazonas. Manaus, AM, Brasil.
Secretaria de Estado da Saúde do Amazonas. Fundação de Medicina Tropical Dr. Heitor Vieira Dourado. Laboratório de Genotipagem de HIV. Manaus, AM, Brasil.
Secretaria de Estado da Saúde do Amazonas. Fundação de Medicina Tropical Dr. Heitor Vieira Dourado. Laboratório de Genotipagem de HIV. Manaus, AM, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de AIDS & Imunologia Molecular. Rio de Janeiro, RJ. Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de AIDS & Imunologia Molecular. Rio de Janeiro, RJ. Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de AIDS & Imunologia Molecular. Rio de Janeiro, RJ. Brasil.
Abstract: The HIV-1 epidemic in Brazil is driven by subtypes B, F1, and C and recombinants forms among those subtypes. The distribution of HIV-1 subtypes, however, may vary across different Brazilian regions and the molecular epidemiologic profile in Northern Brazil remains poorly explored. HIV-1 pol sequences were obtained from 305 patients failing antiretroviral therapy followed at outpatient clinics from five Northern Brazilian states. The most prevalent HIV-1 clade observed in the Northern Brazilian region was subtype B (81%), followed by BF1 recombinants (10%), subtype F1 (4%), subtype C (3%), BC recombinants (2%), and BU recombinants (1%). Although HIV-1 subtype B was the predominant HIV-1 clade in Northern Brazil, its prevalence greatly varies among different states, ranging from 63% in Rondônia to 92% in Acre. Among the 37 HIV-1 recombinant sequences detected in the Northern Brazilian region, nine (24%) displayed a unique recombinant form structure, five (14%) a CRF28/29_BF-like structure, and four (11%) a CRF31_BC-like structure. Two other BF1 recombinant patterns were identified in 16 (43%) and three (8%) samples that may correspond to two potentially new CRFs_BF characteristic of the Northern region. This study reveals that despite the low spatial connectivity with other Brazilian regions, the genetic complexity of the HIV-1 epidemic in Northern Brazil is very high and that the molecular epidemiologic pattern may vary across different northern states, reflecting a complex epidemic with multiple independent viral introductions into this Brazilian region.
Keywords: HIV
Northern region
subtypes
Brazil
keywords: HIV
subtipos
Região Norte
Brasil
Issue Date: 2016
Publisher: Mary Ann Liebert
Citation: COSTA, Carolina Marinho da; et al. High HIV-1 Genetic Diversity in Patients from Northern Brazil. AIDS Research and Human Retroviruses, v.32, n.9, p.918-922, Sept. 2016.
Description: Pré-print do artigo enviado por um dos autores
ISSN: 0889-2229
Copyright: open access
Appears in Collections:IOC - Artigos de Periódicos

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