Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/18656
Title: Larvicidal activity of Ottonia anisum metabolites against Aedes aegypti: A potential natural alternative source for mosquito vector control in Brazil
Authors: Marques, André M.
Velozo, Leosvaldo S.
Carvalho, Michelle A.
Serdeiro, Michele T.
Honório, Nildimar A.
Kaplan, Maria Auxiliadora C.
Maleck, Marise
Affilliation: Universidade Federal do Rio de Janeiro. Centro de Ciências da Saúde. Instituto Walter Mors de Pesquisa em Produtos Naturais. Rio de Janeiro, RJ, Brasil.
Universidade Federal do Rio de Janeiro. Centro de Ciências da Saúde. Instituto Walter Mors de Pesquisa em Produtos Naturais. Rio de Janeiro, RJ, Brasil.
Universidade Severino Sombra. Laboratório de Insetos Vetores. Vassouras, RJ, Brasil.
Universidade Severino Sombra. Laboratório de Insetos Vetores. Vassouras, RJ, Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório Interdisciplinar de Vigilância Entomológica em Diptera e Hemiptera. Rio de Janeiro, RJ. Brasil
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Mosquitos Transmissores de Hematozoários. Rio e Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Núcleo Operacional Sentinela de Mosquitos Vetores. Rio de Janeiro, RJ, Brasil.
Universidade Federal do Rio de Janeiro. Centro de Ciências da Saúde. Instituto Walter Mors de Pesquisa em Produtos Naturais. Rio de Janeiro, RJ, Brasil.
Universidade Severino Sombra. Laboratório de Insetos Vetores. Vassouras, RJ, Brasil / Universidade Severino Sombra. Curso de Mestrado Profissional em Ciências Ambientais. Curso de Mestrado Profissional em Ciências da Saúde. Vassouras, RJ, Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Entomologia Médica e Forense. Rio de Janeiro, RJ, Brasil.
Abstract: Background & objectives: Aedes aegypti mosquito is the principal vector of the viruses responsible for urban yellow fever, dengue, dengue haemorrhagic fever, as well as Zika and chikungunya in Brazil. The present study was aimed to investigate the insecticidal potential of the extract and fractions of Ottonia anisum, along with special metabolites isolated from it, as natural alternatives against larvae (L3) of Ae. aegypti, vector of potentially deadly tropical infections in Brazil. Methods: The plant species O. anisum was collected in March 2015, at Xerém area, in Rio de Janeiro City, Brazil. Crude extracts and the isolated pure compounds were screened for toxicity against Ae. aegypti larvae (L3). Bioassays were performed on 20 larvae (L3) of Ae. aegypti in triplicate. The samples were dissolved in a mixture of acetone and DMSO at final concentrations of 1–200 μg/ml. The toxicity of the solutions was evaluated towards the growth and development of Ae. aegypti larvae till emergence of adults. Results: The crude hexane extract showed 100% larval mortality 24 h after treatment at a concentration of 200 μg/ ml. The bioassays using 1-butyl-3,4-methylenedioxybenzene revealed 100% mortality among L3 larvae, 24 h after the treatment at a concentration of 30 μg/ml, the LC50 recorded was 1.6 μg/ml. At concentration of 10 μg/ml, the L3 larval mortality recorded was 92%. Interpretation & conclusion: The metabolite 1-butyl-3,4-methylenedioxybenzene showed potent toxicity against Ae. aegypti larvae. This arylbutanoid agent could be used as a natural alternative adjuvant pesticide, in new compositions that would be environmentally safer.
Keywords: 1-butyl-3
4-methylenedioxybenzene
Aedes aegypti
dengue
larvicidal activity
Ottonia anisum
Piper
Brazil
keywords: Dengue
Aedes aegypti
Atividade larvicida
Brasil
Issue Date: 2017
Publisher: Medknow Pubications
Citation: MARQUES, André M. et al. Larvicidal activity of Ottonia anisum metabolites against Aedes aegypti: A potential natural alternative source for mosquito vector control in Brazil. J. Vector Borne Dis., v.54, p.61-68, Mar. 2017.
ISSN: 0972-9062
Copyright: open access
Appears in Collections:IOC - Artigos de Periódicos

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