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IDENTIFICATION OF εPKC TARGETS DURING CARDIAC ISCHEMIC INJURY
Author
Affilliation
Stanford University School of Medicine. Department of Chemical and Systems Biology. São Paulo, SP, Brasil.
Instituto do Coração. São Paulo, SP, Brasil.
Stanford University School of Medicine. Department of Chemical and Systems Biology. São Paulo, SP, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ. Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ. Brasil.
Instituto do Coração. São Paulo, SP, Brasil.
tanford University School of Medicine. Department of Chemical and Systems Biology. São Paulo, SP, Brasil.
Universidade de São Paulo. Instituto de Química. Departamento de Bioquímica. São Paulo, SP, Brasil.
Instituto do Coração. São Paulo, SP, Brasil.
Stanford University School of Medicine. Department of Chemical and Systems Biology. São Paulo, SP, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ. Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ. Brasil.
Instituto do Coração. São Paulo, SP, Brasil.
tanford University School of Medicine. Department of Chemical and Systems Biology. São Paulo, SP, Brasil.
Universidade de São Paulo. Instituto de Química. Departamento de Bioquímica. São Paulo, SP, Brasil.
Abstract
Background—Activation of ε protein kinase C (εPKC) protects hearts from ischemic injury.
However, some of the mechanism(s) of εPKC mediated cardioprotection are still unclear.
Identification of εPKC targets may aid to elucidate εPKC–mediated cardioprotective mechanisms.
Previous studies, using a combination of εPKC transgenic mice and difference in gel
electrophoresis (DIGE), identified a number of proteins involved in glucose metabolism, whose
expression was modified by εPKC. These studies, were accompanied by metabolomic analysis,
and suggested that increased glucose oxidation may be responsible for the cardioprotective effect
of εPKC. However, whether these εPKC-mediated alterations were due to differences in protein
expression or phosphorylation was not determined.
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